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Hydroxytacrine maleate

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Formula: C17H18N2O5
CAS: 118909-22-1

Identification

Structural Formula
Hydroxytacrine maleate
CAS:
118909-22-1
EINECS:
Molecular Formula:
C17H18N2O5
MDL:
MFCD00069287
SMILES:
C1CC(C2=C(C3=CC=CC=C3N=C2C1)N)O.C(=CC(=O)O)C(=O)O
Synonym:
velnacrine maleate [usan] ; p 83-6029a ; hydroxytacrine maleate salt ; hydroxytacrine maleate ; velnacrine maleate(hp-029) ; velnacrine maleate ; 1-hydroxy tacrine maleate ; mentane ; hp-029 ; velnacrine hydrogen maleate


Description

Hydroxytacrine maleate is a cholinesterase inhibitor and a potential Alzheimer's therapeutic of low toxicity. Exhibits biochemical and pharmacological profile similar to tacrine (THA) except that it is far less toxic and without measurable liver toxicity in humans. Tacrine is a parasympathomimetic and a centrally acting cholinesterase inhibitor (anticholinesterase). It was the first centrally-acting cholinesterase inhibitor approved for the treatment of Alzheimer's disease, and was marketed under the trade name Cognex. Major form of metabolism is in the liver via hydroxylation of benzylic carbon by CYP450. This forms the major metabolite 1-hydroxy-tacrine (velnacrine) which is still active. Hydroxytacrine maleate is an inhibitor of AChE.


Suppliers

Santa Cruz Biotechnology, Inc.
200168
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Prices & Availability




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Properties for Hydroxytacrine maleate

Molecular Weight:
330.34 g·mol−1
Melting point:
171-173
Solubility:
Soluble in water (5 mg/mL warm), DMSO (25 mg/mL), and ethanol (10 mg/mL).
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Safety & Transport Information

Hazard Symbols:
T
Hazard symbol T
Storage temperature :
-20°C Freezer
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Alternative Distributors of [Hydroxytacrine maleate]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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MSDS:
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