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N-Hydroxysuccinimide

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Formula: C4H5NO3
CAS: 6066-82-6
search Element: hydroxysuccinimide
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Identification

Structural Formula
N-Hydroxysuccinimide
CAS:
6066-82-6
EINECS:
228-001-3
Molecular Formula:
C4H5NO3
MDL:
MFCD00005516
SMILES:
C1CC(=O)N(C1=O)O
Synonym:
nhs or honsu ; honsu ; hosu ; nhs ; n-hydroxysuccinimide ; 1-hydroxysuccinimide ; n-羟基琥珀酰亚胺 99.00% ; hydroxysuccinimide ; n-hydroxysuccinimde ; akos 91864


Description

N-Hydroxysuccinimide, commonly known as NHS, is a hydroxylated succinimide that is widely used in the activation of carboxylic acids to NHS-esters to promote coupling with nucleophiles. This approach is most commonly employed in activating the free acid forms of fluorophores for promoting conjugation of these fluorophores to amine residues of proteins. Use of NHS ester activation has also been described in the synthesis of N-acyl amino acids.


Suppliers

Aozeal Certified Standards (AOCS), Inc.
N0082.00
+
Shandong Ench Chemical Co.,Ltd
SECC6003000
+
Krada CPS Industry S.L
KCIS4402200
+
Wuhan PharmChem Co., LTD.
WP5001500
+
Shandong Minglang Chemical Co., Ltd
SMC7002800
+
OPQ Chemical Co., Ltd
OC4201260
+
Lori Industry Co., Ltd
LI4401320
+
Shandong SanYoung Industry Co., Ltd
SSI7002800
+
Refine Chemical Co.,Ltd.
RCC4801920
+
Create Chemical Co., Ltd.
CC5001500
+
Chemlyte Solutions
CS3601080
+
Autech Industry Co.,Limited
AIC5402160
+
Shandong Lanhai Industry Co.,Ltd.
SLIC6603300
+
H&Z Industry Co.,Ltd
HIC4001600
+
Unilong Industry Co.,Ltd
UIC4801920
+
Indofine Chemical Co, Inc.
04-1830
Nanjing Chemical Material Corp
NCMC6003000
+
Pt. Sarana Bela Nusa
PSBN4002000
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT10205100
+
Fabrichem, Inc.
F300600
Xiamen Equation Chemical Co.,Ltd
XECC6403200
+
Sancai Industry Co.,Ltd.
SIC4801920
+
Aecochem Corp.
AC280840
+
Merck Schuchardt OHG
MSO4001600
Hangzhou Keying Chem Co., Ltd.
HKC6002400
+
scienTEST - bioKEMIX GmbH
S-B5002000
+
Hangzhou Ocean Chemical Co., Ltd.
HOC6602640
+
Carbone Scientific Co., Ltd.
CS5601680
+
Xiamen Hisunny Chemical Co., Ltd.
XHC6602640
+
AK Scientific, Inc.
AS3801140
+
Xiamen Kinbester Co., Ltd.
XK5201560
+
DSL Chemicals (Shanghai) Co., Ltd.
C003137
Simagchem Corporation
SC4201260
+
Xingrui Industry Co., Limited
XIL5802320
+
Capot Chemical Co., Ltd.
10972
+
Zehao Industry Co., Ltd.
ZI4801440
+
Santa Cruz Biotechnology, Inc.
219162
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CAS equal suppliers

HOSu
GL Biochem (Shanghai) Ltd.
10501
HOSU
Pt. Sarana Bela Nusa
PSBN80400
HO-Su
Iris Biotech GmbH
RL-1038.1000
N-Hydroxy succinamide
GM Chemsys
Gmc-sp072
NHS,N-Hydroxysuccinimide
Huateng Pharmaceutical Co.,Ltd
812031
N-HYDROXYSUCCINIMIDE (NHS)
DKSH International AG
DIA10924368
N-Hydroxysuccinimide, 98+%
Alfa (A Johnson Matthey Company)
A8322496
N-Hydroxysuccinimide, 98+%
Acros Organics BVBA
AOB4941976
N-Hydroxysuccinimide, HOSu
Hainan Zhongxin Chemical Co., Ltd.
HZC17687072
N-Hydroxysuccinimide, HOSu
Biesterfeld Spezialchemie GmbH
BS15604680
N-Hydroxysuccinimide, HOSu
Organo Fine Chemicals
OFC10924368
N-Hydroxysuccinimide, HOSu
CM Fine Chemicals
CFC8843536
N-Hydroxysuccinimide, HOSu
Acinopeptide Co., Ltd.
A11442288
N-Hydroxysuccinimide, HOSu
Leap Chem Co., Ltd
LC9362808
N-Hydroxysuccinimide, HOSu
Shanghai UCHEM Inc.
UCHEM-4218
N-Hydroxysuccinimide, HOSu
Hangzhou J&H Chemical Co., Ltd.
HJC16126448
N-Hydroxysuccinimide, HOSu
Zhejiang Hongxin Chemical
ZHC13005200
N-Hydroxysuccinimide, HOSu
Puyer BioPharma Ltd.
PB10403120
N-Hydroxysuccinimide, HOSu
Daming Changda Co., Ltd.
DC12483744
N-Hydroxysuccinimide, HOSu
Skyrun Industrial Co., Ltd.
SI14044212
N-Hydroxysuccinimide, HOSu
Changzhou Weijia Chemical Co.,Ltd. -WJCHEM-
CWCC-228816016
N-Hydroxysuccinimide, HOSu
Haihang Industry Co., Ltd.
HI13524056
N-Hydroxysuccinimide, HOSu
Shanghai Yayu Biomedical Co., Ltd
SYB17166864
N-Hydroxysuccinimide, HOSu
Iris Biotech GmbH
RL-1038.1000
N-Hydroxysuccinimide, HOSu
Wanko Chemical Co., Ltd.
WC12483744
N-Hydroxysuccinimide, HOSu
Hangzhou Ocean Chemical Co., Ltd.
HOC17166864
N-Hydroxysuccinimide, HOSu
Lonwin Industry Group Limited
LIGL15087540
N-Hydroxysuccinimide (HOSu)
Molekula
58561996
1-Hydroxy-2,5-pyrrolidinedione
BLD Pharmatech Ltd
BP10803240
1-Hydroxypyrrolidine-2,5-dione
Hangzhou MolCore BioPharmatech Co.,Ltd.
CS19674
1-Hydroxypyrrolidine-2,5-dione
Ambeed, Inc.
A171441
1-Hydroxypyrrolidine-2,5-dione
Manchester Organics Limited
U56368
N-Hydroxy succinimide for synthesis
Indenta Chemicals (India) Pvt. Ltd.
IC490019600
N-Hydroxysuccinimide [Coupling Reagent for Peptide]
TCI Chemicals (India) Pvt. Ltd.
B0249

Prices & Availability




Data is processed


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Properties for N-Hydroxysuccinimide

Molecular Weight:
115.09 g·mol−1
Density:
~1.6 g/cm3 (Predicted)
Melting point:
95-98 °C(lit.)
Boiling point:
~262.4° C at 760 mmHg (Predicted)
Solubility:
Soluble in water (50 mg/ml), DMSO (100 mM), methanol, acetone (50 mg/ml), and DMF.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
2-8°C
x

Alternative Distributors of [N-Hydroxysuccinimide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Fischer Chemicals AG | Xinchem Corporation | Hisyntech Corporation Limited | Rongkang Industry Co.,Ltd - (NSTU Chemicals Hanggzhou Co.,) | Nanjing R&M Fine Chemical Co., Ltd. | Chem-Impex International, Inc. | Shanghai International Pharmaceutical Co., Ltd. | Hallochem Pharma Co., Ltd. | YiXing Jeneral Import & Export Co., Ltd. | Wuhan CheMax Chemical Industrial Co., Ltd. | Shanghai Eagle Chemical Co., Ltd. | Hangzhou Think Chemical Co., Ltd. | Molekula GmbH | Xiang Ding Chemical International Co., Ltd | ABCR GmbH & Co. KG | East Chemical Industry Co., Ltd. | Pharmasi Chemicals Co., Ltd. | TCI Europe NV | Wintersun Chemical | Honour Enterprise Limited | Tanabe Europe N.V. | Zibo Panxin Pharmaceutical Co., Ltd. | Long Island Pharmaceutical & Chemical Co. Ltd. | Unispec Chemicals Co. | Ubichem PLC | Suzhou Rovathin Pharmatech Co., Ltd | Lanospharma Laboratories Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | AOKBIO Co., Ltd. | Jinan Great Chemical Co., Ltd. | Grandachem Ltd. | Zouping Mingxing Chemical Co., Ltd. | Suzhou Sibian Chemical Technology Co., Ltd. | Shanghai Sunwise Chemical Co., Ltd. | Insight Finechem Co., Ltd. | Watson International Ltd | Chengdu Conut Intl. Co., Ltd. | BOC Sciences | Wolves R&D Chemicals | Hangzhou Ocean Chemical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Finetech Industry Limited | Genchem & Genpharm (Changzhou) Co., Ltd. | Pfaltz & Bauer, Inc. | Sino Rarechem Labs Co. Ltd. | scienTEST | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | DKSH International AG

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