2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid | CAS 64054-40-6

Element: pyrrolidineheptanoic hydroxyoctyl acid

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C-S » Chemicals » hydroxyoctyl-oxo-pyrrolidineheptanoic-acid-PX55631

Identification

2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid

CAS:

64054-40-6

EINECS:

Molecular Formula:

C₁₉H₃₅NO₄

MDL:

MFCD11976917

SMILES:

CCCCCC(CCC1CCC(=O)N1CCCCCCC(=O)O)O

Synonym:

1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo-

Description

2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Kι = 35 nM) relative to the EP1, EP2, and EP3 receptors (Kι = 3,000, 2,000, and >3,000 nM, respectively). This chemical stimulates cAMP formation in excised murine ovaries. Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that plays important roles in bone formation and resorption, cancer and atherosclerosis by elevating the second messenger cAMP.

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Properties for 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid

Molecular Weight:

341.5 g·mol−1

Boiling point:

78° C

Solubility:

Soluble in water (2.5 mg/ml at 25° C), PBS (pH 7.2) (~2.5 mg/ml), DMF (~10 mg/ml), DMSO (~10 mg/ml), and ethanol.

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Alternative Distributors of [2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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Mol File:

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MSDS:

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