9-Hydroxyellipticine, Hydrochloride | CAS 52238-35-4

Element: hydroxyellipticine hydrochloride

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Identification

9-Hydroxyellipticine, Hydrochloride

CAS:

52238-35-4

EINECS:

Molecular Formula:

C₁₇H₁₄N₂O

MDL:

SMILES:

CC1=C2C=CN=CC2=C(C3=C1NC4=C3C=C(C=C4)O)C.Cl

Synonym:

Hydroxyellipticine

Description

9-Hydroxyellipticine, Hydrochloride is a cell-permeable antitumor alkaloid that acts as a potent inhibitor of Topo II (IC₅₀ = 3.3 μM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes

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Santa Cruz Biotechnology, Inc.

203940

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CAS equal suppliers

9-Hydroxyellipticine hydrochloride

Santa Cruz Biotechnology, Inc.

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9-Hydroxyellipticine Hydrochloride

ShangHai Biochempartner Co., Ltd.

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6H-pyrido[4,3-b]carbazol-9-ol, 5,11-dimethyl-, monohydrochloride

Angene International Limited

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Prices & Availability

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Properties for 9-Hydroxyellipticine, Hydrochloride

Molecular Weight:

262.3059 g·mol−1

Density:

1.349 g/cm3

Boiling point:

557.7°C at 760 mmHg

Flash point:

291.1°C

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Alternative Distributors of [9-Hydroxyellipticine, Hydrochloride]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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