22(R)-hydroxycholesterol | CAS 17954-98-2

Element: hydroxycholesterol

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C-S » Chemicals » hydroxycholesterol-PX81824

Identification

22(R)-hydroxycholesterol

CAS:

17954-98-2

EINECS:

Molecular Formula:

C₂₇H₄₆O₂

MDL:

MFCD00070042

SMILES:

C[C@@H]([C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C)[C@@H](CCC(C)C)O

Synonym:

cholest-5-ene-3,22-diol,(3b,22r)- ; 22beta-hydroxycholesterol ; 22(r)-hydroxycholesterol ; 22r-ohc ; 22a-hydroxycholesterol ; 22-hydroxycholesterol (22r) ; (22r)-hydroxycholesterol ; cholest-5-ene-3b,22(r)-diol ; 22(r)-oh-ch ; 22bf-hydroxycholesterol ; 5-cholestene-3β,22(r)-diol ; narthesterol ; 5-cholestene-3β,22[r]-diol ; 22α-hydroxycholesterol ; (22r)-cholest-5-ene-3b,22-diol ; (22r)-22-hydroxycholesterol ; cholest-5-ene-3b,22-diol, (20s,22r)- (8ci)

Description

22(R)-hydroxy Cholesterol is an endogenous agonist for the oxysterol receptor, LXR (liver X receptor) which upon activation stimulates epidermal differentiation and development while inhibiting keratinocyte proliferation. LXRs also regulate the metabolism of cholesterol by increasing the transcription of the ABCA1 gene, which promotes cholesterol efflux and HDL formation. In addition, 22(R)-hydroxy cholesterol produces an elevation in CYP3A mRNA concentrations which is mediated by the pregnane X receptor (PXR). Studies suggest that 22(R)-hydroxy cholesterol promotes the transcription of the CYP7A1 gene via activation of LXRα receptors in rats. Furthermore, CYP7A1 activity promoted by LXRα can be inhibited downstream by FXR.

Suppliers

Leap Chem Co., Ltd

LC8642592

Santa Cruz Biotechnology, Inc.

205106

Dayang Chem (Hangzhou) Co.,Ltd.

DC14885952

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Prices & Availability

Data is processed

Properties for 22(R)-hydroxycholesterol

Molecular Weight:

402.6529 g·mol−1

Density:

1.03 g/cm3

Melting point:

186.51° C (Predicted)

Boiling point:

513.1 °C at 760 mmHg

Flash point:

213.5 °C

Solubility:

Soluble in chloroform (20 mg/ml), water (0.5 mg/ml at 25.0° C), ethanol (~20 mg/ml), DMSO (~0.1 mg/ml), and DMF (~2 mg/ml).

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Alternative Distributors of [22(R)-hydroxycholesterol]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd.