ML-7 hydrochloride | CAS 110448-33-4

Element: hydrochloride

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C-S » Chemicals » hydrochloride-PX78335

Identification

ML-7 hydrochloride

CAS:

110448-33-4

EINECS:

Molecular Formula:

C₁₅H₁₈ClIN₂O₂S

MDL:

MFCD00065524

SMILES:

C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl

Synonym:

1-(5-iodonaphthalene-1-sulfonyl)-1h-*hex ahydro-1,4- ; 1-(5-iodonaphthalene-1-sulfonyl)-1h-*hexahydro-1, ; 1-(5-iodonaphthalene-1-sulfonyl)-1h-hexahydro-1,4-diazepine hcl ; 1-((5-iodonaphthalen-1-yl)sulfonyl)-1,4-diazepane hydrochloride ; ml-7, hcl ; ml 7 hydrochloride, >=98% ; 1-(5-iodonaphthalene-1-sulfonyl)homopiperazine, hcl ; 1-(5-iodonaphthalene-1-sulfonyl)-1h-hexahydro-1,4-diazepine ; ml-7 hydrochloride ; ml-7

Description

ML-7 has been shown to inhibit Ca²⁺ dependent and independent smooth muscle MYLK (myosin light chain kinases) via competitive inhibition of ATP and also inhibits PKC and PKA. This compound also inhibits cell transporters activated by shrinkage and affects the osmotic volume regulation of cells. Mechanistic studies suggest that this is done via stimulation of K-CL cotransport, a cell volume regulating agent. ML-7 has also been reported to affect the superoxide O₂^--producing system of human neutrophils in a myosin light chain kinase independent manner.

Suppliers

Aea.ltd

A252504

Santa Cruz Biotechnology, Inc.

200557

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Prices & Availability

Data is processed

Properties for ML-7 hydrochloride

Molecular Weight:

452.74 g·mol−1

Melting point:

246-249 °C dec.

Solubility:

Soluble in water (Partly miscible), DMSO (10 mg/ml), 50% aq. ethanol (10 mg/ml), methanol, and 100% warm ethanol.

Safety & Transport Information

Storage temperature :

-20°C

Alternative Distributors of [ML-7 hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd. | Sino Rarechem Labs Co. Ltd. | D&P Global Chemical Co., Ltd