BX 513 hydrochloride | CAS 193542-65-3

Element: hydrochloride

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C-S » Chemicals » hydrochloride-PX77604

Identification

BX 513 hydrochloride

CAS:

193542-65-3

EINECS:

Molecular Formula:

C₂₈H₂₉ClN₂O.HCl

MDL:

MFCD09971135

SMILES:

Cl.N#CC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)(c1ccccc1)c1ccccc1

Synonym:

bx 513 hydrochloride ; 4-(4-chlorophenyl)-4-hydroxy-a,a-diphenyl-1-piperidinepentanenitrile hydrochloride ; 4-(4-chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrilehydrochloride

Description

Inhibits MIP-1α-induced intracellular calcium mobilization (IC₅₀ = 2.5 μM). Selective CCR1 receptor antagonist (K_i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). A full inverse agonist at US28, a HCMV-encoded chemokine receptor.