NE 100 hydrochloride | CAS 149409-57-4

Element: hydrochloride

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C-S » Chemicals » hydrochloride-PX73963

Identification

NE 100 hydrochloride

CAS:

149409-57-4

EINECS:

Molecular Formula:

C₂₃H₃₃NO₂.HCl

MDL:

MFCD00922105

SMILES:

CCCN(CCC)CCC1=CC(=C(C=C1)OC)OCCC2=CC=CC=C2.Cl

Synonym:

4-methoxy-3-(2-phenylethoxy)-n,n-dipropylbenzeneethanaminehydrochloride ; n,n-dipropyl-2-(4-methoxy-3-(2-phenylethoxy)phenyl)ethylamine monohydrochloride ; ne 100 hydrochloride ; ne-100 ; n,n-di-n-propyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl] ethylamine hydrochloride

Description

NE 100 hydrochloride is a potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. NE 100 hydrochloride displays antipsychotic activity in vivo and additionallt Exhibits reversible binding (Kd = 1.2 nM).