AH 11110 hydrochloride | CAS 179388-65-9

Element: hydrochloride 11110

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Identification

AH 11110 hydrochloride

CAS:

179388-65-9

EINECS:

Molecular Formula:

C₂₁H₂₆ N₂ O₂ . Cl H

MDL:

SMILES:

C1CCN(CC1)C(=N)CC(COC2=CC=CC=C2C3=CC=CC=C3)O.Cl

Synonym:

Piperidine,1-[4-([1,1'-biphenyl]-2-yloxy)-3-hydroxy-1-iminobutyl]-, monohydrochloride(9CI) ; AH 11110A ; 1-Piperidinepropanol, a-[([1,1'-biphenyl]-2-yloxy)methyl]-g-imino-, hydrochloride (1:1)

Description

AH 11110 hydrochloride is a subtype-selective ligand for the α1B-adrenoceptor (α1B-AR). The pK_i values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. AH 11110 hydrochloride appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.