GW 3965 hydrochloride | CAS 405911-17-3

Element: hydrochloride 3965

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C-S » Chemicals » hydrochloride-PX55336

Identification

GW 3965 hydrochloride

CAS:

405911-17-3

EINECS:

Molecular Formula:

C₃₃H₃₁ClF₃NO₃.HCl

MDL:

MFCD08276920

SMILES:

C1=CC=C(C=C1)C(CN(CCCOC2=CC=CC(=C2)CC(=O)O)CC3=C(C(=CC=C3)C(F)(F)F)Cl)C4=CC=CC=C4.Cl

Synonym:

Description

GW 3965 hydrochloride is a non-steroidal agonist of LXR (liver X receptor), which specifically induces LXRα (hLXRα) and LXRβ (hLXRβ). Cell-free ligand-sensing assays involving GW 3965 hydrochloride indicate that LXRα (hLXRα) is favored over LXRβ (hLXRβ). Alternate studies suggest that GW 3965 hydrochloride upregulates ABC1 (ABCA1) in low density lipoprotein-loaded macrophages. Since ABC1 (ABCA1) is a major regulator of cholesterol and phospholipid metabolism, GW 3965 hydrochloride is a useful tool to study these cellular functions.

Suppliers

Allfluoro Pharmaceutical Co. Ltd.

APC13865544

BOC Sciences

BS5041512

Leap Chem Co., Ltd

LC7562268

Santa Cruz Biotechnology, Inc.

224011

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CAS equal suppliers

GW3965 HCl

ShangHai Biochempartner Co., Ltd.

BCP03049

GW3965 HCl

Excenen Pharmatech Co., Ltd.

EN-3379

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CSNpharm, Inc.

CSN12844

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Ambeed, Inc.

A150197

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Leap Chem Co., Ltd

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Hefei Hirisun Pharmatech Co., Ltd

HR110047

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Finipharma Ltd

F2156043120

2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride

Autech Industry Co.,Limited

AIC41580166320

Prices & Availability

Data is processed

Properties for GW 3965 hydrochloride

Molecular Weight:

618.51 g·mol−1

Boiling point:

692° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (124 mg/ml at 25° C), water (<1 mg/ml at 25° C), and ethanol (20 mM).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Alternative Distributors of [GW 3965 hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ShangHai Biochempartner Co., Ltd. | Shanghai Insight Chemicals Co., Ltd.