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Histone Lysine Methyltransferase Inhibitor

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Formula: C28H38N6O2.3ClH.H2O
CAS: 935693-62-2

Identification

Structural Formula
Histone Lysine Methyltransferase Inhibitor
CAS:
935693-62-2
EINECS:
Molecular Formula:
C28H38N6O2.3ClH.H2O
MDL:
SMILES:
CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC
Synonym:
bix 01294 ; histone lysine methyltransferase inhibitor ; bix 01294 (free base) ; 4-quinazolinamine, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]- ; bix 01294 hydrate trihydrochloride ; bix 01294, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride


Description

Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a (histone lysine methyltransferase (HMTase)) inhibitor, specifically shown to inhibit the G9a-mediated generation of H3K9me2 (histone H3 lysine 9 dimethylation), not competitive with the S-adenosyl-methionine cofactor. Levels of H3K9me2 are restored with removal of BIX-01294. This molecule allows transient modulation of HMTase behavior, providing a tool for studying consequent effects on gene expression and chromatin organization. Histone Lysine Methyltransferase Inhibitor is an inhibitor of EHMT.


Suppliers

Santa Cruz Biotechnology, Inc.
202651
Dayang Chem (Hangzhou) Co.,Ltd.
DC520820832
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CAS equal suppliers

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Amadis Chemical Company Limited
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Salsbury Chemicals, Inc.
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BIX01294 free base
Excenen Pharmatech Co., Ltd.
EX-A582
BIX01294 hydrochloride
Santa Cruz Biotechnology, Inc.
sc-293525
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Hangzhou MolCore BioPharmatech Co.,Ltd.
MC443128
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
Capot Chemical Co., Ltd.
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2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
CM Fine Chemicals
CFC26180104720
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
Leap Chem Co., Ltd
LC2772083160
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine
Finipharma Ltd
F2156043120
4-Quinazolinamine, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-
Angene International Limited
AGN-PC-04ZOLM
Bix 01294, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride
Gihi Chemicals Co., Limited
GCL67014268056

Prices & Availability




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Properties for Histone Lysine Methyltransferase Inhibitor

Molecular Weight:
618.046 g·mol−1
Solubility:
Soluble in water (100 mM), DMSO (5 mg/ml), and ethanol.
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Safety & Transport Information

Storage temperature :
2-8°C
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Alternative Distributors of [Histone Lysine Methyltransferase Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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