Histone Lysine Methyltransferase Inhibitor | CAS 935693-62-2

Element: methyltransferase inhibitor histone lysine

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C-S » Chemicals » histone-lysine-methyltransferase-inhibitor-PX4098

Identification

Histone Lysine Methyltransferase Inhibitor

CAS:

935693-62-2

EINECS:

Molecular Formula:

C₂₈H₃₈N₆O₂.3ClH.H₂O

MDL:

SMILES:

CN1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)CC5=CC=CC=C5)OC)OC

Synonym:

bix 01294 ; histone lysine methyltransferase inhibitor ; bix 01294 (free base) ; 4-quinazolinamine, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]- ; bix 01294 hydrate trihydrochloride ; bix 01294, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinaminetrihydrochloride ; 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride

Description

Histone Lysine Methyltransferase Inhibitor (BIX-01294) is a G9a (histone lysine methyltransferase (HMTase)) inhibitor, specifically shown to inhibit the G9a-mediated generation of H3K9me2 (histone H3 lysine 9 dimethylation), not competitive with the S-adenosyl-methionine cofactor. Levels of H3K9me2 are restored with removal of BIX-01294. This molecule allows transient modulation of HMTase behavior, providing a tool for studying consequent effects on gene expression and chromatin organization. Histone Lysine Methyltransferase Inhibitor is an inhibitor of EHMT.

Suppliers

Santa Cruz Biotechnology, Inc.

202651

Dayang Chem (Hangzhou) Co.,Ltd.

DC520820832

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CAS equal suppliers

BIX-01294

Pharmacore Co., Limited

PL207621

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ShangHai Biochempartner Co., Ltd.

BCP06426

BIX-01294

Ambeed, Inc.

A337768

BIX-01294

CSNpharm, Inc.

CSN15763

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Amadis Chemical Company Limited

ACCL2791395

BIX-01924

Salsbury Chemicals, Inc.

SC216648

BIX01294 free base

Excenen Pharmatech Co., Ltd.

EX-A582

BIX01294 hydrochloride

Santa Cruz Biotechnology, Inc.

sc-293525

N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC443128

N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine

Capot Chemical Co., Ltd.

34125

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

CM Fine Chemicals

CFC26180104720

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

Leap Chem Co., Ltd

LC2772083160

2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine

Finipharma Ltd

F2156043120

4-Quinazolinamine, 2-(hexahydro-4-methyl-1h-1,4-diazepin-1-yl)-6,7-dimethoxy-n-[1-(phenylmethyl)-4-piperidinyl]-

Angene International Limited

AGN-PC-04ZOLM

Bix 01294, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine hydrate trihydrochloride

Gihi Chemicals Co., Limited

GCL67014268056

Prices & Availability

Data is processed

Properties for Histone Lysine Methyltransferase Inhibitor

Molecular Weight:

618.046 g·mol−1

Solubility:

Soluble in water (100 mM), DMSO (5 mg/ml), and ethanol.

Safety & Transport Information

Storage temperature :

2-8°C

Alternative Distributors of [Histone Lysine Methyltransferase Inhibitor]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.

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MSDS:

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