1,2,3,4,5,6-HEXABROMOCYCLOHEXANE | CAS 1837-91-8

Element: hexabromocyclohexane

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C-S » Chemicals » hexabromocyclohexane-PX74701

Identification

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

CAS:

1837-91-8

EINECS:

Molecular Formula:

C₆H₆ Br₆

MDL:

MFCD00059127

SMILES:

C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br

Synonym:

cyclohexane,1,2,3,4,5,6-hexabromo- ; jak2 inhibitor ii ; 1,2,3,4,5,6-hexabromocyclohexane ; trans-α-benzene hexabromide ; nsc 7908 ; 1,2,3,4,5,6-hexabromo-cyclohexan ; benzene hexabromide ; 1,2,3,4,5,6-hexabromcyclohexan

Description

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation. In silico simulation indicates that 1,2,3,4,5,6-Hexabromocyclohexane accesses a binding pocket positioned adjacent to the activation loop on the JAK2 protein. Growth hormone-mediated JAK2 autophosphorylation was greatly reduced by 1,2,3,4,5,6-Hexabromocyclohexane, and it was shown to not block autophosphorylation of the epidermal growth factor receptor.

Suppliers

Carbone Scientific Co., Ltd.

CS8962688

Santa Cruz Biotechnology, Inc.

202398

Dayang Chem (Hangzhou) Co.,Ltd.

DC9923968

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CAS equal suppliers

Cyclohexane, 1,2,3,4,5,6-hexabromo-

Angene International Limited

AGN-PC-0JLBQ3

Prices & Availability

Data is processed

Properties for 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Molecular Weight:

557.54 g·mol−1

Density:

2.90 g/cm³ (Predicted)

Melting point:

218-223° C

Boiling point:

388.88° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (5 mg/ml).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R36 - Irritating to eyes
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection

Hazard Symbols:

Storage temperature :

Store at RT

Alternative Distributors of [1,2,3,4,5,6-HEXABROMOCYCLOHEXANE]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

ABCR GmbH & Co. KG | TCI Europe NV

Downloads

Mol File:

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MSDS:

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