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Herbimycin A

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Formula: C30H42N2O9
CAS: 70563-58-5
search Element: herbimycin
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Identification

Structural Formula
Herbimycin A
CAS:
70563-58-5
EINECS:
Molecular Formula:
C30H42N2O9
MDL:
MFCD00151702
SMILES:
CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)C(C)=CC=C/[C@H](OC)[C@@H](OC(N)=O)C(C)=C[C@H](C)[C@H]1OC)C2=O
Synonym:
antibiotictan420f ; herbimycin a, streptomyces hygroscopicus ; herbimycin, tan 420f ; (15r)-geldanamyci ; herbimycin ; herbimycin a ; herbimycin a, streptomyces species ; c11225 ; herbimycin a from streptomyces*hygroscopicus ; herbimycin a, streptomyces sp.


Description

Herbimycin A, a benzoquinoid ansamycin antibiotic, is produced by the actinomycetes organism Streptomyces hygroscopicus and has antiparasite and antineoplastic properties. Herbimycin A irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups. Herbimycin A inhibits c-Abl, HSP 90, c-Src, c-Yes (Yes), Fes (Fps), Ros, and EGFR (ErbB) oncogene products and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C. Herbimycin A also inhibits platelet derived growth factor induced phospholipase D activation. Herbimycin A is an angiogenesis inhibitor and has potent herbicidal activity against most mono- and di-cotyledenous plants, especially against Cyperus microiria STEUD. Oryza sativa shows strong resistance to herbimycin.


Suppliers

Leap Chem Co., Ltd
LC4321296
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Santa Cruz Biotechnology, Inc.
3516
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Prices & Availability




Data is processed


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Properties for Herbimycin A

Molecular Weight:
574.66 g·mol−1
Density:
~1.2 g/cm3 (Predicted)
Boiling point:
~752.4° C at 760 mmHg (Predicted)
Solubility:
DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [Herbimycin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH | Jinan Great Chemical Co., Ltd. | Molekula GmbH | Clearsynth Canada INC. | East Chemical Industry Co., Ltd.

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Downloads

Mol File:
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MSDS:
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