Ginsenoside Rf

Ginsenoside Rf, a glycoside of protopanaxatriol from Panax ginseng, is shown to be a biologically active saponin found to regulate lipoprotein metabolism. Mechanistic studies report that this regulation is done via altering of peroxisome proliferator-activated receptor α (PPARα)-mediated pathways. PPARα has demonstrated the ability to regulate C-III mRNA and basal levels of hepatic apoA-I (apolipoprotein A-I) which affect lipoprotein metabolism. Additional experiments have also observed this Ginsenoside Rf's ability to inhibit Ca²⁺ channels in mammalian sensory neurons in vitro.