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Geldanamycin

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Formula: C29H40N2O9
CAS: 30562-34-6
search Element: geldanamycin

Identification

Structural Formula
Geldanamycin
CAS:
30562-34-6
EINECS:
Molecular Formula:
C29H40N2O9
MDL:
MFCD00274570
SMILES:
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)C)C)O)OC
Synonym:
geldanamycin ; nsc122750 ; geldanamycin, 99+% ; cp-122634 ; geldanamycin from stre ; geldanamycin (gdm) ; streptomyces hygroscopicus ; nsc 212518 ; geldanamycln ; ga


Description

Geldanamycin, a benzoquinone ansamycin, has been found to revert tyrosine kinase-induced oncogenic transformation. In the same study it was reported that Geldanamycin was able to bind elements of Hsp90 (heat shock protein 90) clients, such as HIF-1α (Hypoxia-inducible factor-1-α), and inhibit them. Geldanamycin binds in a specific and stable manner and as a result inhibits new protein maturation. Geldanamycin binds with high affinity into the ATP binding pocket of Hsp90. These heat shock proteins might positively impact cell proliferation by being a chaperone required for the assembly and activation of telomerase in cells. By binding them, Geldanamycin is thought to reduce new protein maturation and their downstream transcriptional activity. Geldanamycin has also displayed a capacity to bind to the endoplasmic reticulum homologue of the heat-shock protein, GP-96 and thus interferes with the cellular stress response. In addition, Geldanamycin has been reported as a potent inhibitor of the nuclear hormone receptor family. Other research has demonstrated Geldanamycin to be a protective agent against α-synuclein toxicity to dopaminergic neurons in Drosophila. Geldanamycin is an inhibitor of c-Src.


Suppliers

Ambeed, Inc.
A164935
Shandong SanYoung Industry Co., Ltd
SSI4201680
Nantong Xindao Biotech Ltd
NXB3121248
Shanghai Chong Da Prostaglandin Fine Chemicals Co., Ltd.
SCDPFC6724704
Indofine Chemical Co, Inc.
Bio-187
BoomKing Industrial Co.,Limited
BIC3721488
Xiamen Equation Chemical Co.,Ltd
XECC3841920
CSNpharm, Inc.
CSN11085
Hangzhou Keying Chem Co., Ltd.
HKC3601440
scienTEST - bioKEMIX GmbH
S-B3001200
Finetech Industry Limited
FIL3001200
Iris Biotech GmbH
LS-1031.0000
AK Scientific, Inc.
AS228684
Simagchem Corporation
SC252756
BOC Sciences
BS144432
Leap Chem Co., Ltd
LC216648
Santa Cruz Biotechnology, Inc.
200617
Dayang Chem (Hangzhou) Co.,Ltd.
DC3721488
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CAS equal suppliers

Geldanamycin, 99+%
Alfa (A Johnson Matthey Company)
A5761728
Geldanamycin (Streptomyces hygroscopicus) 98+%
United States Biological
G2024-50
Geldanamycin, 1mg/mL in DMSO, sterile-filtered
Alfa (A Johnson Matthey Company)
A883226496
[(8Z,12Z,14Z)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate
Iris Biotech GmbH
LS-1031
(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
BLD Pharmatech Ltd
BP57114171342

Prices & Availability




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Properties for Geldanamycin

Molecular Weight:
560.64 g·mol−1
Density:
~1.2 g/cm3 (Predicted)
Melting point:
255 °C
Boiling point:
~783.9° C at 760 mmHg (Predicted)
Solubility:
DMSO: soluble
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Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S27 - Take off immediately all contaminated clothing
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Hazard Symbols:
T, Xi
Hazard symbol T Hazard symbol Xi
Storage temperature :
-20°C
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Alternative Distributors of [Geldanamycin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

World Biopharma Group Limited / World (Jiangsu) Industry Co.,Ltd | Molekula GmbH | Taizhou Crene Biotechnology Co., Ltd. | Chemexcel International Ltd. | World Industry Co. Ltd., (Factory) | Sanowart Group Co., Ltd. | ShangHai Biochempartner Co., Ltd. | Discovery Fine Chemicals Limited | SYNCHEM OHG | Hangzhou Think Chemical Co., Ltd. | Kinfon Pharmaceutical and Chemical Service Co., Ltd. | Hangzhou Sida Organic Chemical Co., Ltd. | Anix-Chem Limited | Lanospharma Laboratories Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Jinan Great Chemical Co., Ltd. | Carl Roth GmbH + Co KG | Jinjiangchem Corporation | Shanghai Witofly Chemical Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Cfm Oskar Tropitzsch GmbH | Watson International Ltd | BOC Sciences | Bestlife Biological Technology Co., Ltd | Fermentek Ltd. | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | scienTEST | Gihi Chemicals Co., Limited

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