Gefitinib | CAS 184475-35-2 | Chemical-Suppliers

Element: gefitinib

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C-S » Chemicals » gefitinib-PX77752

Identification

Gefitinib

CAS:

184475-35-2

EINECS:

Molecular Formula:

C₂₂H₂₄ClFN₄O₃

MDL:

MFCD04307832

SMILES:

COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4

Synonym:

gifitinib ; getfitnib ; iressa ; gefinitib ; gefitinib ; gefitinib, >=99% ; zd 1839 ; gefitinib(tinibs) ; gefitinib ws ; akos 91371

Description

Gefitinib is an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor and has been shown to increase phosphorylation of c-Jun NH₂-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) in HaCaT cells. Studies suggest that gefitinib can enhance keratinocyte apoptosis via an EGFR-independent JNK-activation pathway. Research indicates that gefitinib can induce apoptosis in several cell lines including, HaCaT cells, KG-1, P39, and primary CD34+ myeloblasts. Erlotinib has similar properties to gefitinib.

Suppliers

FUDI Chemical Co. Ltd.

FCC198792

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

H&Z Industry Co.,Ltd

HIC180720

Autech Industry Co.,Limited

AIC243972

Aea.ltd

A63126

Shandong SanYoung Industry Co., Ltd

SSI3151260

Ambeed, Inc.

A109874

Chemlyte Solutions

CS162486

JieJie Group Co., Ltd.

JG198594

Arcadia Biotechnology

AB189567

BoomKing Industrial Co.,Limited

BIC2791116

Xiamen Equation Chemical Co.,Ltd

XECC2881440

Shanghai UCHEM Inc.

UCHEM-5576

Sancai Industry Co.,Ltd.

SIC216864

Fox Chemicals GmbH

FC162486

CSNpharm, Inc.

CSN11084

Hangzhou Lingrui Chemical Co., Ltd.

HLC3151260

Finetech Industry Limited

FIL225900

Hefei Hirisun Pharmatech Co., Ltd

HR131019

CM Fine Chemicals

CFC153612

AK Scientific, Inc.

AS171513

Xingrui Industry Co., Limited

XIL2611044

Capot Chemical Co., Ltd.

30298

BOC Sciences

BS108324

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

202166

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CAS equal suppliers

Iressa

Molekula

57220562

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine

Wanko Chemical Co., Ltd.

WC1706451192

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine

Suzhou Vosun Biotech Co.,Ltd

SVBC28560142800

N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine

BLD Pharmatech Ltd

BP1836055080

Prices & Availability

Data is processed

Properties for Gefitinib

Molecular Weight:

446.9 g·mol−1

Density:

~1.3 g/cm³ (Predicted)

Melting point:

119-1200C

Boiling point:

~586.8° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (89 mg/ml at 25° C), methanol (20 mg/ml), ethanol (4 mg/ml at 25° C), DMF (20 mg/ml), and water (<1 mg/ml at 25° C).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Storage temperature :

Store at RT

Alternative Distributors of [Gefitinib]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified