Ro 48-8071 fumarate | CAS 189197-69-1

Element: fumarate 8071

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C-S » Chemicals » fumarate-PX74862

Identification

Ro 48-8071 fumarate

CAS:

189197-69-1

EINECS:

Molecular Formula:

C₂₃H₂₇BrFNO₂

MDL:

MFCD05865242

SMILES:

CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C.C(=C/C(=O)O)C(=O)O

Synonym:

Methanone, (4-bromophenyl)[2-fluoro-4-[[6-(methyl-2-propenylamino)hexyl]oxy]phenyl]-,(2E)-2-butenedioate

Description

Ro 48-8071 fumarate is an orally active 2,3-oxidosqualene lanosterol cyclase (OSC) inhibitor where OSC represents a unique target for a cholesterol-lowering drug. Partial inhibition of OSC should reduce synthesis of lanosterol and subsequent sterols, and also stimulate the production of epoxysterols that repress HMG-CoA reductase expression, generating a synergistic, self-limited negative regulatory loop.