FTY720 Phosphate | CAS 402615-91-2

Element: phosphate fty720

Page Content Identification Properties Suppliers Prices & Availability Get Quick Quote ☰

Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » fty-phosphate-PX69108

Identification

FTY720 Phosphate

CAS:

402615-91-2

EINECS:

Molecular Formula:

C₁₉H₃₄NO₅P

MDL:

MFCD18251416

SMILES:

CCCCCCCCC1=CC=C(C=C1)CCC(CO)(COP(=O)(O)O)N

Synonym:

fty720-p ; rac fty720-d4 phosphate ; 1,3-propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, mono(dihydrogen phosphate) (ester) ; fty-p-d4 ; racfty720 phosphate ; fty720-p-d4 ; fty-p ; fingolimod phosphate ; 2-amino-2-(hydroxymethyl)-4-(4-octylphenyl)butyl dihydrogen phosphate ; fty720 phosphate ; fingolimod phosphate d4

Description

FTY720 Phosphate is a derivative of ISP-1 (myriocin) that is a fungal metabolite of the Chinese herb Iscaria sinclarii and a structural analog of sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. It is phosphorylated by sphingosine kinase to the physiologically active phosphoric acid ester. FTY720 phosphate acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (EDG-1, EDG-3, EDG-4, and EDG-5), with IC₅₀ values of 0.2-6 nM.