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From Egyptian scorpion: [Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, Cys20-Cys35] H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-P

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Formula: C158H249 N53 O47 S11
CAS: 163515-35-3
search Element: egyptian scorpion cys16 cys19 cys20 cys28 cys33 cys35 cys2 cys5 from
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Identification

Structural Formula
From Egyptian scorpion: [Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, Cys20-Cys35] H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-P
CAS:
163515-35-3
EINECS:
Molecular Formula:
C158H249 N53 O47 S11
MDL:
MFCD00239920
Synonym:
Chlorotoxin(Leiurus quinquestriatus) (9CI) ; 65: PN: WO2008088422 FIGURE: 8 claimedprotein ; 67: PN: WO2006116156 SEQID: 67 claimed protein ; Chlorotoxin ; L-Argininamide,L-methionyl-L-cysteinyl-L-methionyl-L-prolyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-threonyl-L-a-aspartyl-L-histidyl-L-glutaminyl-L-methionyl-L-alanyl-L-arginyl-L-lysyl-L-cysteinyl-L-a-aspartyl-L-a-aspartyl-L-cysteinyl-L-cysteinylglycylglycyl-L-lysylglycyl-L-arginylglycyl-L-lysyl-L-cysteinyl-L-tyrosylglycyl-L-prolyl-L-glutaminyl-L-cysteinyl-L-leucyl-L-cysteinyl-,cyclic (2® ; 19),(5® ; 28),(16® ; 33),(20® ; 35)-tetrakis(disulfide)


Description

Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpion Leiurus quinquestriatus. The toxin has recently been reported to specifically bind to a protein complex on the surface of glioma cells containing several proteins implicated in glioma cell invasion and thus inhibit their invasive potential. Gelatinase A (matrix metalloproteinase-2 (MMP2)) is one of the components present in this complex. The anti-invasive effect of chlorotoxin seems to be mediated by binding to and direct inhibition of gelatinase A, and its surface down-regulation. Chlorotoxin is available in bulk quantities, produced according to cGMP. References:


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Properties for From Egyptian scorpion: [Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, Cys20-Cys35] H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-P

Molecular Weight:
4004.76 g·mol−1
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Alternative Distributors of [From Egyptian scorpion: [Cys2-Cys19, Cys5-Cys28, Cys16-Cys33, Cys20-Cys35] H-Met-Cys-Met-Pro-Cys-Phe-Thr-Thr-Asp-His-Gln-Met-Ala-Arg-Lys-Cys-Asp-Asp-Cys-Cys-Gly-Gly-Lys-Gly-Arg-Gly-Lys-Cys-Tyr-Gly-P]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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