N1-Fmoc-N2,N3-bis-Boc-triethylene-tetramine-N4-succinamic acid

Orthogonally protected oligoethylenimine-based amino acids are versatile cationic building blocks useful as polycationic carriers for nucleic acid delivery or in the synthesis of peptides with increased positive charge density. Use of these building blocks in solid-phase synthesis showed full compatibility with standard Fmoc SPPS protocols and the excellent purity of the resulting poly(amidoamines). Linear and branched sequences can be synthesized, optionally fused with natural peptide sequences. Reference: D. Schaffert, N. Badgujar, E. Wagner; Org. Lett. 2011; 13(7): 1586-1589.