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Flurbiprofen

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Formula: C15H13FO2
CAS: 5104-49-4
search Element: flurbiprofen

Identification

Structural Formula
Flurbiprofen
CAS:
5104-49-4
EINECS:
225-827-6
Molecular Formula:
C15H13FO2
MDL:
MFCD00079303
SMILES:
CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O
Synonym:
u-27182 ; zepolas ; cebutid ; adfeed ; antadys ; fp70 ; stayban ; froben ; anside ; ansaid


Description

Flurbiprofen is a mixture of S(+) and R(-) enantiomers. Flurbiprofen is a cell-permeable, non-steroidal anti-inflammatory (NSAID) agent that acts as a potent inhibitor of Cox-1 (cyclooxygenase-1) and Cox-2 (cyclooxygenase-2) (IC50 = 5 nM for LPS-induced Cox in human peripheral blood cells). The S(+) enantiomer is reported to be more potent as a Cox-2 inhibitor than the R(-) enantiomer. Flurbiprofen suppresses iNOS expression in RAW 264.7 macrophages. It reduces Aβ loads and Congo Red staining in APP+PS1 transgenic mice.


Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI8283312
H&Z Industry Co.,Ltd
HIC240960
Wuhan PharmChem Co., LTD.
WP300900
Chemlyte Solutions
CS216648
Ambeed, Inc.
A481951
Xiamen Equation Chemical Co.,Ltd
XECC3841920
Sancai Industry Co.,Ltd.
SIC2881152
Aecochem Corp.
AC168504
CSNpharm, Inc.
CSN11044
Wanko Chemical Co., Ltd.
WC288864
Sigma-Aldrich International GmbH
SI3841152
Carbone Scientific Co., Ltd.
CS3361008
AK Scientific, Inc.
AS228684
Xingrui Industry Co., Limited
XIL3481392
Leap Chem Co., Ltd
LC216648
Santa Cruz Biotechnology, Inc.
202158
Dayang Chem (Hangzhou) Co.,Ltd.
DC3721488
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CAS equal suppliers

ANSAID
ShangHai Biochempartner Co., Ltd.
BCP09086
2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid
BLD Pharmatech Ltd
BP592217766
2-Fluoro-alpha-methyl-4-biphenylacetic Acid (flurbiprofen)
Molekula
26685423

Prices & Availability




Data is processed


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Properties for Flurbiprofen

Molecular Weight:
244.26 g·mol−1
Density:
1.2 g/cm3 (Predicted)
Melting point:
110-112 °C(lit.)
Boiling point:
376.23° C at 760 mmHg (Predicted)
Solubility:
Soluble in DMSO (50 mg/ml), methanol (50 mg/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml), and buffers of ionic strength ≥0.1 M and pH ≥7.4 (~5 mg/ml). Insoluble in water.
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:
R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R25 - Toxic if swallowed
Safety Codes:
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
Hazard Classes:
6.1(b)
Hazard Symbols:
T, C
Hazard symbol T Hazard symbol C
Storage temperature :
Store at RT
RID/ADR certification :
UN 2811 6.1 / PG 2
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Alternative Distributors of [Flurbiprofen]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Spectrum Chemical Mfg. Corp. | Inter-Chemical Ltd. | Hallochem Pharma Co., Ltd. | 3B Scientific Corporation | ABCR GmbH & Co. KG | Molekula GmbH | Xiang Ding Chemical International Co., Ltd | TCI Europe NV | Taizhou Huading Chemical Co., Ltd. | New Dragon Industrial Co., Ltd | Zibo Panxin Pharmaceutical Co., Ltd. | Chengdu Qiaofeng Technological Development Co., Ltd. | Suzhou Rovathin Pharmatech Co., Ltd | Chemrio International Limited | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Atomole Scientific Co., Ltd. | Lanospharma Laboratories Co., Ltd. | ZCL Chemicals Ltd | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Sino Rarechem Labs Co. Ltd. | Clearsynth Canada INC. | Haihang Industry Co., Ltd.

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