Flurbiprofen | CAS 5104-49-4 | Chemical-Suppliers

Element: flurbiprofen

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C-S » Chemicals » flurbiprofen-PX71022

Identification

Flurbiprofen

CAS:

5104-49-4

EINECS:

225-827-6

Molecular Formula:

C₁₅H₁₃FO₂

MDL:

MFCD00079303

SMILES:

CC(C1=CC(=C(C=C1)C2=CC=CC=C2)F)C(=O)O

Synonym:

u-27182 ; zepolas ; cebutid ; adfeed ; antadys ; fp70 ; stayban ; froben ; anside ; ansaid

Description

Flurbiprofen is a mixture of S(+) and R(-) enantiomers. Flurbiprofen is a cell-permeable, non-steroidal anti-inflammatory (NSAID) agent that acts as a potent inhibitor of Cox-1 (cyclooxygenase-1) and Cox-2 (cyclooxygenase-2) (IC₅₀ = 5 nM for LPS-induced Cox in human peripheral blood cells). The S(+) enantiomer is reported to be more potent as a Cox-2 inhibitor than the R(-) enantiomer. Flurbiprofen suppresses iNOS expression in RAW 264.7 macrophages. It reduces Aβ loads and Congo Red staining in APP+PS1 transgenic mice.

Suppliers

Ambeed, Inc.

A481951

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI8283312

H&Z Industry Co.,Ltd

HIC240960

Wuhan PharmChem Co., LTD.

WP300900

Chemlyte Solutions

CS216648

Xiamen Equation Chemical Co.,Ltd

XECC3841920

Sancai Industry Co.,Ltd.

SIC2881152

Aecochem Corp.

AC168504

CSNpharm, Inc.

CSN11044

Wanko Chemical Co., Ltd.

WC288864

Sigma-Aldrich International GmbH

SI3841152

Carbone Scientific Co., Ltd.

CS3361008

AK Scientific, Inc.

AS228684

Xingrui Industry Co., Limited

XIL3481392

Leap Chem Co., Ltd

LC216648

Santa Cruz Biotechnology, Inc.

202158

Dayang Chem (Hangzhou) Co.,Ltd.

DC3721488

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CAS equal suppliers

ANSAID

ShangHai Biochempartner Co., Ltd.

BCP09086

2-(2-Fluoro-[1,1'-biphenyl]-4-yl)propanoic acid

BLD Pharmatech Ltd

BP592217766

2-Fluoro-alpha-methyl-4-biphenylacetic Acid (flurbiprofen)

Molekula

26685423

Prices & Availability

Data is processed

Properties for Flurbiprofen

Molecular Weight:

244.26 g·mol−1

Density:

1.2 g/cm³ (Predicted)

Melting point:

110-112 °C(lit.)

Boiling point:

376.23° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (50 mg/ml), methanol (50 mg/ml), ethanol (~100 mg/ml), DMF (~100 mg/ml), and buffers of ionic strength ≥0.1 M and pH ≥7.4 (~5 mg/ml). Insoluble in water.

Hazard Statements

GHS06
Toxic

Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:

R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed
R25 - Toxic if swallowed

Safety Codes:

S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Classes:

6.1(b)

Hazard Symbols:

T, C

Storage temperature :

Store at RT

RID/ADR certification :

UN 2811 6.1 / PG 2

Alternative Distributors of [Flurbiprofen]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified