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Flavopiridol Hydrochloride

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Formula: C21H20ClNO5 HCl
CAS: 131740-09-5

Identification

Structural Formula
Flavopiridol Hydrochloride
CAS:
131740-09-5
EINECS:
Molecular Formula:
C21H20ClNO5 HCl
MDL:
MFCD26792554
SMILES:
CN1CCC([C@@H](C1)O)C2=C(C=C(C3=C2OC(CC3=O)C4=CC=CC=C4Cl)O)O.Cl
Synonym:
alvocidib hydrochloride ; flavopiridol hcl ; flavopiridol hci ; hl 275 ; nsc 649890 hcl ; l-86-8276 ; alvocidib hcl ; flavopiridol hydrochloride ; nsc 649890 ; mdl 107826a


Description

Flavopiridol is a synthetic flavonoid based on an extract from Dysoxylum binectariferum which has shown potential for treatment of cancer in vitro. Flavopiridol hydrochloride is a potent inhibitor of cyclin-dependent kinases (primarily Cdk1, Cdk2, and Cdk4) with an IC50 of 100 nM. The (-)-cis form induces apoptosis in particular tumor cells. At nanomolar concentrations, flavoporidol hydrochloride has been shown to reduce rhabdoid cell growth with an IC50 ranging from 50 to 200 nM. Treatment of flavopiridol decreased the activities of Cdk2 and potently prevented cell proliferation with an IC50 ranging from 43 to 83 nM in HNSCC cells.


Suppliers

Ambeed, Inc.
A180731
Aea.ltd
A364728
BOC Sciences
BS6241872
Leap Chem Co., Ltd
LC9362808
Santa Cruz Biotechnology, Inc.
207687
Dayang Chem (Hangzhou) Co.,Ltd.
DC16126448
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CAS equal suppliers

Alvocidib HCL
Aea.ltd
A182364
Flavopiridol HCl
CSNpharm, Inc.
CSN11015
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one hydrochloride
BLD Pharmatech Ltd
BP2916087480
2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one hydrochloride
Chemlyte Solutions
CS2916087480

Prices & Availability




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Properties for Flavopiridol Hydrochloride

Molecular Weight:
438.3 g·mol−1
Melting point:
169.5-170 °C
Solubility:
Soluble in DMSO (88 mg/ml at 25° C), methanol, water (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
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Safety & Transport Information

Risk Codes:
R22 - Harmful if swallowed
Hazard Symbols:
Xn
Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Flavopiridol Hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences | Jinan Great Chemical Co., Ltd. | SYNCHEM OHG | Trademax Phamaceuticals & Chemicals Co., Ltd. | Zhejiang Esun Chemical Co., Ltd. | Clearsynth Canada INC. | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Marketing Center of Yangzhou Princechem Co., Ltd. | ShangHai Biochempartner Co., Ltd. | East Chemical Industry Co., Ltd. | Shanghai Witofly Chemical Co., Ltd.

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