FABP4 Inhibitor | CAS 300657-03-8

Element: inhibitor fabp4

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C-S » Chemicals » fabp-inhibitor-PX72930

Identification

FABP4 Inhibitor

CAS:

300657-03-8

EINECS:

Molecular Formula:

C₃₁H₂₆ N₂ O₃

MDL:

MFCD09991687

SMILES:

CCC1=C(C(=NN1C2=CC=CC=C2C3=CC(=CC=C3)OCC(=O)O)C4=CC=CC=C4)C5=CC=CC=C5

Synonym:

2''-(5-ethyl-3,4-diphenyl-pyrazol-1-yl)-biphenyl-3-yloxy]acetic acid ; acetic acid,2-[[2'-(5-ethyl-3,4-diphenyl-1h-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]- ; 2-[[2'-(5-ethyl-3,4-diphenyl-1h-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]- acetic acid ; aceticacid, [[2'-(5-ethyl-3,4-diphenyl-1h-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-(9ci)

Description

FABP4 Inhibitor is a cell-permeable biphenylazolo-oxyacetate that acts as a potent and selective inhibitor of A-FABP (adipocyte Fatty-Acid-Binding Protein) by targeting its fatty acid-binding pocket (K_i = < 2 nM in a competitive binding assay using 1,8-ANS), while exhibiting much lower affinity for muscle and epidermal FABP's (K_i = 250 nM and 350 nM, respectively). FABP4 Inhibitor (A-FABP Inhibitor) has been shown to effectively block foam cell transformation and the cellular expression of inflammatory mediators in aP2-positive, but not aP2-negative, THP-1 macrophage in vitro, as well as improve the glucose metabolism and insulin sensitivity.

Suppliers

Santa Cruz Biotechnology, Inc.

202606

Dayang Chem (Hangzhou) Co.,Ltd.

DC9303720

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CAS equal suppliers

BMS309403

Excenen Pharmatech Co., Ltd.

EX-A1147

BMS309403

Aea.ltd

A63126

BMS-309403

CSNpharm, Inc.

CSN22610

[2'-(5-Ethyl-3,4-diphenyl-pyrazol-1-yl)-biphenyl-3-yloxy]-acetic acid

3B (Wuhan) Scientific Corporation

31821654648

2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]acetic acid

Leap Chem Co., Ltd

LC1749652488

2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]acetic acid

Finipharma Ltd

F1360827216

2-[[2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]acetic acid

BLD Pharmatech Ltd

BP1749652488

2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC100533

Prices & Availability

Data is processed

Properties for FABP4 Inhibitor

Molecular Weight:

474.557 g·mol−1

Density:

1.17

Melting point:

305.01° C (Predicted)

Boiling point:

657.51° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO, methanol, and ethanol.

Safety & Transport Information

coming up soon

Alternative Distributors of [FABP4 Inhibitor]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Sanowart Group Co., Ltd. | Anix-Chem Limited | ShangHai Biochempartner Co., Ltd. | Sino Rarechem Labs Co. Ltd.

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