Ezetimibe | CAS 163222-33-1 | Chemical-Suppliers

Element: ezetimibe

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C-S » Chemicals » ezetimibe-PX77969

Identification

Ezetimibe

CAS:

163222-33-1

EINECS:

Molecular Formula:

C₂₄H₂₁F₂NO₃

MDL:

MFCD00937872

SMILES:

O[C@@H](CCC1[C@H](N(C1=O)C1=CC=C(F)C=C1)C1=CC=C(O)C=C1)C1=CC=C(F)C=C1

Synonym:

ezetimide ; zetia ; ezetimib ; ezitimibe&int ; ezatimibe ; ezetimibe ; sch-58235 ; zetia/vytorin ; ezetimibe, >=99% ; sch 60969

Description

Ezetimibe has been reported to be a cholesterol transport inhibitor. Mechanistic studies show that this compound directly affects Niemann-Pick C1-like 1 (NPC1L1) and prevents it from incorporating into clathrin-coated vesicles. NPC1L1 is a polytopic transmembrane protein that facilitates absorption of cholesterol via clathrin/AP2-mediated endocytosis. By binding to NPC1L1, ezetimibe prevents endocytosis of this protein therefore blocking cholesterol transfer across membranes. Ezetimibe is used clinically to lower plasma cholesterol levels.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Shandong SanYoung Industry Co., Ltd

SSI3151260

Autech Industry Co.,Limited

AIC243972

Chemlyte Solutions

CS162486

Ambeed, Inc.

A124629

H&Z Industry Co.,Ltd

HIC180720

Aozeal Certified Standards (AOCS), Inc.

E0011.00

Guangzhou Topwork Chemical Co., Ltd.

GTC3241296

Hangzhou Cherry Pharmaceutical Technology Co., Ltd.

HCPT4592295

Chemvon Biotechnology Co. Ltd.

CBC2701080

BoomKing Industrial Co.,Limited

BIC2791116

Sancai Industry Co.,Ltd.

SIC216864

CSNpharm, Inc.

CSN12575

Hangzhou Lingrui Chemical Co., Ltd.

HLC3151260

Wanko Chemical Co., Ltd.

WC216648

Finetech Industry Limited

FIL225900

Carbone Scientific Co., Ltd.

CS252756

Hefei Hirisun Pharmatech Co., Ltd

HR110026

AK Scientific, Inc.

AS171513

Simagchem Corporation

SC189567

Xingrui Industry Co., Limited

XIL2611044

BOC Sciences

BS108324

Amadis Chemical Company Limited

ACCL2791395

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

205690

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(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one (ezetimibe)

Fond Chemical Co.Ltd,

FCC45885183540

Prices & Availability

Data is processed

Properties for Ezetimibe

Molecular Weight:

409.43 g·mol−1

Density:

1.34 g/cm³ (Predicted)

Melting point:

164-166°C

Boiling point:

654.88° C at 760 mmHg (Predicted)

Solubility:

Soluble in water (<1 mg/ml at 25° C), alcohols, DMSO (82 mg/ml at 25° C), ethanol (82 mg/ml at 25° C), and methanol.

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Storage temperature :

-20°C Freezer

Alternative Distributors of [Ezetimibe]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified