Evodiamine | CAS 518-17-2 | Chemical-Suppliers

Element: evodiamine

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C-S » Chemicals » evodiamine-PX72195

Identification

Evodiamine

CAS:

518-17-2

EINECS:

Molecular Formula:

C₁₉H₁₇N₃O

MDL:

MFCD06407824

SMILES:

CN1C2C3=C(CCN2C(=O)C4=CC=CC=C41)C5=CC=CC=C5N3

Synonym:

evodiamine 5% plant extract ; evodiamine(6ci,7ci,8ci) ; indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7h)-one,8,13,13b,14-tetrahydro-14-methyl-, (13bs)- ; evodiamine, (+)- ; d-evodiamine ; indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7h)-one, 8,13,13b,14-tetrahydro-14-methyl-, (13bs)- ; (+)-evodiamine ; evodiamine.p.e ; c09187 ; evodiamine(isoevodiamine) ; evodiamine std. ; indolo[2',3':3,4]pyrido[2,1-b]quinazolin-5(7h)-one,8,13,13b,14-tetrahydro-14-methyl-, (s)- ; evodiamine 98% ; evodiamine ; evodia rutaecarpa e.p. ; isoevodiamine

Description

Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin. Evodiamine induction of ⁴⁵Ca²⁺ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine. Evodiamine is described to inhibit prostaglandin E₂ synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects. The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.

Suppliers

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6902760

Chengdu Pufeide Biotech. Co., Ltd

CPB3301320

H&Z Industry Co.,Ltd

HIC200800

Autech Industry Co.,Limited

AIC2701080

Shandong SanYoung Industry Co., Ltd

SSI3501400

Chemlyte Solutions

CS180540

Indofine Chemical Co, Inc.

06-574

Arcadia Biotechnology

AB210630

Alfa (A Johnson Matthey Company)

A320960

X´ian Taicheng Chem Co., Ltd

XTC2901160

Xiamen Equation Chemical Co.,Ltd

XECC3201600

Carbone Scientific Co., Ltd.

CS280840

Simagchem Corporation

SC210630

Xingrui Industry Co., Limited

XIL2901160

Capot Chemical Co., Ltd.

18244

Santa Cruz Biotechnology, Inc.

201479

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CAS equal suppliers

(+/-)-Evodiamine

Acinopeptide Co., Ltd.

A7041408

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Evonik ( formerly Wilshire Technologies, Inc. )

E15366144

(+/-)-Evodiamine

Leap Chem Co., Ltd

LC5761728

(+/-)-Evodiamine

Hangzhou J&H Chemical Co., Ltd.

HJC9923968

(+/-)-Evodiamine

Daming Changda Co., Ltd.

LLB00801

(+/-)-Evodiamine

Medibro Corporation Limited

MCL8643456

(+/-)-Evodiamine

Skyrun Industrial Co., Ltd.

SI8642592

(+/-)-Evodiamine

LGM Pharma

LP320960

(+/-)-Evodiamine

Haihang Industry Co., Ltd.

HI8322496

(+/-)-Evodiamine

Hangzhou Lingrui Chemical Co., Ltd.

HLC11204480

Evodia Rutaecarpa

Nantong Xindao Biotech Ltd

NXB8843536

Prices & Availability

Data is processed

Properties for Evodiamine

Molecular Weight:

303.3578 g·mol−1

Density:

1.39 g/cm3

Melting point:

278° C

Boiling point:

575.1 °C at 760 mmHg

Flash point:

301.6 °C

Solubility:

Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25° C, and ethanol (<1 mg/mL) at 25° C.

Transport Information:

UN 2811 6.1/PG 3

Safety & Transport Information

Risk Codes:

R25 - Toxic if swallowed

Safety Codes:

S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)

Hazard Symbols:

Storage temperature :

2-8°C

RID/ADR certification :

UN 2811 6.1 / PG 3

Alternative Distributors of [Evodiamine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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