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(-)-Epigallocatechin Gallate

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Formula: C22H18O11
CAS: 989-51-5
search Element: epigallocatechin gallate
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Identification

Structural Formula
(-)-Epigallocatechin Gallate
CAS:
989-51-5
EINECS:
Molecular Formula:
C22H18O11
MDL:
MFCD00075940
SMILES:
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Synonym:
teavigo(tm) ; (-)-egcg ; e-5187 ; egcg-d6 ; ecgc ; teavigo tg ; egcg90% ; teavigo ; tea catechin ; egcg


Description

(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).


Suppliers

Lori Industry Co., Ltd
LI18485544
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI579623184
+
Chemlyte Solutions
CS15124536
+
Ambeed, Inc.
A110153
+
Hangzhou Cherry Pharmaceutical Technology Co., Ltd.
HCPT428421420
+
Alfa (A Johnson Matthey Company)
A26888064
Xiamen Equation Chemical Co.,Ltd
XECC268813440
+
Sancai Industry Co.,Ltd.
SIC20168064
+
Aecochem Corp.
AC11763528
+
CSNpharm, Inc.
CSN16836
Finetech Industry Limited
FIL21008400
+
Carbone Scientific Co., Ltd.
CS23527056
+
Simagchem Corporation
SC17645292
+
Capot Chemical Co., Ltd.
25635
+
Zehao Industry Co., Ltd.
ZI20166048
+
BOC Sciences
BS10083024
+
Santa Cruz Biotechnology, Inc.
200802
Dayang Chem (Hangzhou) Co.,Ltd.
DC260410416
+
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Neostar United Industrial Co., Ltd.
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Haihang Industry Co., Ltd.
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Pharmacore Co., Limited
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R&D Scientific Inc.
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Shandong SanYoung Industry Co., Ltd
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Jiwan Pharmaceutical Technology Co., Ltd.
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AK Scientific, Inc.
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Salsbury Chemicals, Inc.
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Prices & Availability




Data is processed


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Properties for (-)-Epigallocatechin Gallate

Molecular Weight:
458.37 g·mol−1
Density:
1.90 g/cm3 at 20° C
Melting point:
222-224 °C
Boiling point:
909.11° C at 760 mmHg
Solubility:
Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol.
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Storage temperature :
2-8°C
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Alternative Distributors of [(-)-Epigallocatechin Gallate]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Hangzhou Mole´s Science & Technology Co.,Ltd. | Taizhou Chemedir Biopharm-Tech Co., Ltd. | AK Scientific, Inc. | Shanghai Tauto Biotech Co., Ltd. | Jinan Great Chemical Co., Ltd. | Carl Roth GmbH + Co KG | 3Way Pharm Inc. | Shanxi Zishan Natural Technology Co., Ltd. | East Chemical Industry Co., Ltd. | Chemland International Co.,Ltd. | Cfm Oskar Tropitzsch GmbH | BOC Sciences | Suzhou Bichal Biological Technology Co., Ltd. | Hubei Yuancheng Saichuang Tech.Co.,Ltd | Finetech Industry Limited | Jinan Haohua Industry Co., Ltd. | Clearsynth Canada INC. | Xiamen Hisunny Chemical Co., Ltd.

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