8-epi-Prostaglandin F2α

8-epi PGF2α is a biologically active isoprostane produced by the non-enzymatic free radical catalyzed peroxidation of arachidonic acid. This compound has demonstrated potent vasoconstriction activity in rat lung and kidney where its effects seem to be mediated through agonist activity at thromboxane receptors; however, evidence exists for a separate and distinct isoprostane receptor. 8-epi PGF2α is also a mitogen in 3T3 cells and in vascular smooth muscle cells, and may play a role in pulmonary oxygen toxicity. Research has suggested that measurement of 8-epi PGF2α concentration could be used as a non-invasive indicator of oxidative stress, and that this compound may act in vivo as a signaling molecule of oxidative stress. 8-epi-Prostaglandin F2α is an activator of TXA2R.