Embelin

Embelin, a cell permeable 1,4-Benzoquinone-derivative originally isolated from Embelia ribes, has been shown to contain antiproliferative characteristics in 3-Methylcholanthrene-induced fibrosarcoma in albino rats. This compound has also been reported to be an antinociceptive and antiinflammatory agent. Additionally, Embelin has been found to display antibacterial potential against 3 strains of 12 bacteria. Other studies have reported Embelin to have apoptosis induction capabilities through binding of BIR3 domain of XIAP (X-linked inhibitor of apoptosis protein). The antioxidant capabilities of Embelin have also been studied and mechanistic studies suggest that Embelin has a tendency to scavenge DPPH (sc-202591) radicals and inhibit hydroxyl radical induced deoxyribose degradation. This compound prevents the activation of NF-κB by inhibiting IKK. Embelin is an inhibitor of PCAF and XIAP and an activator of caspase-9.