Eicosatrienoic Acid (5Z,11Z,14Z)

Eicosatrienoic Acid (5Z,11Z,14Z) is a polyunsaturated fatty acid found in various natural sources including maritime pine (Pinus pinaster) seed oil (MPSO), gymnospermae leaves and seeds, and freshwater gastropods. A diet containing MPSO lowered high-density lipoprotein and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to diminish cholesterol efflux in vitro. 5Z,11Z,14Z-Eicosatrienoic acid methyl ester, when topically applied, diminishes inflammatory processes, potentially by displacing arachidonic acid from phospholipid pools and reducing downstream inflammatory products such as prostaglandin E2 and leukotrienes.