Doxorubicin hydrochloride | CAS 25316-40-9

Element: hydrochloride doxorubicin

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Identification Properties Suppliers Prices & Availability Get Quick Quote

C-S » Chemicals » doxorubicin-hydrochloride-PX77503

Identification

Doxorubicin hydrochloride

CAS:

25316-40-9

EINECS:

246-818-3

Molecular Formula:

C₂₇H₂₉NO₁₁.HCl

MDL:

MFCD00077757

SMILES:

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl

Synonym:

fi 106 ; caely ; caelyx ; adriacin ; adr ; dox hcl ; ardriamycin ; lipodox ; fi6804 ; dox

Description

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once it associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II) This general mechanism gives it efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR.

Suppliers

H&Z Industry Co.,Ltd

HIC10004000

XD BIOCHEMS Ltd

XB7502250

Shandong SanYoung Industry Co., Ltd

SSI17507000

Nantong Xindao Biotech Ltd

NXB13005200

Aozeal Certified Standards (AOCS), Inc.

D0059.00

Chemlyte Solutions

CS9002700

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI345013800

Shandong Minglang Chemical Co., Ltd

SMC17507000

Lori Industry Co., Ltd

LI11003300

Autech Industry Co.,Limited

AIC13505400

Indofine Chemical Co, Inc.

Bio-172

Guangzhou Topwork Chemical Co., Ltd.

GTC18007200

Xiamen Equation Chemical Co.,Ltd

XECC16008000

Sancai Industry Co.,Ltd.

SIC12004800

Aecochem Corp.

AC7002100

scienTEST - bioKEMIX GmbH

S-B12505000

Finetech Industry Limited

FIL12505000

AK Scientific, Inc.

AS9502850

Xingrui Industry Co., Limited

XIL14505800

Zehao Industry Co., Ltd.

ZI12003600

BOC Sciences

BS6001800

Amadis Chemical Company Limited

ACCL15507750

Santa Cruz Biotechnology, Inc.

200923

Dayang Chem (Hangzhou) Co.,Ltd.

DC15506200

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Key Organics Limited

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Excenen Pharmatech Co., Ltd.

EX-A1337

(8S,10S)-10-(((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride

BLD Pharmatech Ltd

BP79920239760

Prices & Availability

Data is processed

Properties for Doxorubicin hydrochloride

Molecular Weight:

579.98 g·mol−1

Melting point:

216 °C (dec.)(lit.)

Boiling point:

810.3° C at 760 mmHg

Solubility:

H₂O: 10 mg/mL, clear, red-orange

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R22 - Harmful if swallowed
R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed
R36/38 - Irritating to eyes and skin
R40 - Limited evidence of a carcinogenic effect
R45 - May cause cancer

Safety Codes:

S22 - Do not breathe dust
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
S7/9 - Keep container tightly closed and in a well-ventilated place

Hazard Symbols:

T, T+, Xi

Storage temperature :

2-8°C

Alternative Distributors of [Doxorubicin hydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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Mol File:

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MSDS:

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