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Donepezil

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Formula: C24H29NO3
CAS: 120014-06-4
search Element: donepezil
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Identification

Structural Formula
Donepezil
CAS:
120014-06-4
EINECS:
Molecular Formula:
C24H29NO3
MDL:
MFCD00912833
SMILES:
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
Synonym:
donepezil, >=99% ; donepezil hcl (base) ; donepezil ; n-1-one ; akos 226-23 ; donepezil hydrochloride monohydra ; donepezil intermediate ; donezepil ; donepezil hydrochloride monohydrate ; 2-[(1-benzyl-4-piper


Description

Donepezil is a noncompetitive acetylcholineesterase inhibitor, which can readily cross the blood brain barrier and increase the concentration of cortical acetylcholine. It is known that Donepezil is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil selectively inhibits acetylcholineesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.


Suppliers

Ambeed, Inc.
A127504
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6212484
+
H&Z Industry Co.,Ltd
HIC180720
+
Shandong SanYoung Industry Co., Ltd
SSI3151260
+
Chemlyte Solutions
CS162486
+
Aozeal Certified Standards (AOCS), Inc.
D0004.14
+
Xiamen Equation Chemical Co.,Ltd
XECC2881440
+
CSNpharm, Inc.
CSN16651
scienTEST - bioKEMIX GmbH
S-B225900
+
Finetech Industry Limited
FIL225900
+
Xingrui Industry Co., Limited
XIL2611044
+
BOC Sciences
BS108324
+
Leap Chem Co., Ltd
LC162486
+
Santa Cruz Biotechnology, Inc.
279006
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Prices & Availability




Data is processed


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Properties for Donepezil

Molecular Weight:
379.49 g·mol−1
Density:
~1.1 g/cm3 (Predicted)
Melting point:
207 °C
Boiling point:
~527.9 °C at 760 mmHg (Predicted)
Solubility:
Soluble in chloroform (~50 mg/ml), and acetone (~25 mg/ml).
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
RID/ADR certification :
UN 2811
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Alternative Distributors of [Donepezil]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Hebei Oxen Special Chemicals Company Limited | Molekula GmbH | Hangzhou Onicon Chemical Co., Ltd. | Argosi International Co., Ltd. | Tianjin Pharmacn Medical Technology Co., Ltd. | Zhejiang Materials Industry Chemical Group Co., Ltd. | Conier Chem & Pharma Ltd | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Lanospharma Laboratories Co., Ltd. | Jinan Great Chemical Co., Ltd. | Bepharm Ltd. | East Chemical Industry Co., Ltd. | Zhejiang Kaili Industrial Co., Ltd. | Changzhou Weijia Chemical Co.,Ltd. -WJCHEM- | Watson International Ltd | BOC Sciences | Chongqing Land Tower Pharmaceutical Co., Ltd. | Jinan Haohua Industry Co., Ltd. | Gihi Chemicals Co., Limited | Clearsynth Canada INC. | scienTEST

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