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N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester

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Formula: C13H15 N O5
CAS: 778624-05-8

Identification

Structural Formula
N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester
CAS:
778624-05-8
EINECS:
Molecular Formula:
C13H15 N O5
MDL:
Synonym:
l-alanine,n-[(2e)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-, methyl ester (9ci) ; l-alanine,n-[(2e)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]-, methyl ester ; n-[(2e)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-l-alanine, methyl ester ; 3,4-dihydrocinnamic acid (l-alanine methyl ester) amide ; cay10487


Description

N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, inhibits formation of fatty streak lesions of the thoracic aorta, which characterize early stage atherosclerosis, in high cholesterol-fed rabbits without significantly inhibiting ACAT-1 or ACAT-2 activity or affecting plasma lipid profiles. The percent area occupied by the atherosclerotic lesion in rabbits supplemented with 0.05% N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, in the diet was 16.1% compared to 53.5% in control rabbits. N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester, also exhibits antioxidant activity, inhibiting copper-mediated oxidation of low-density lipoprotein by about 75% at a concentration of 2 µM.


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Santa Cruz Biotechnology, Inc.
205398
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Properties for N-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-L-alanine, methyl ester

Molecular Weight:
265.26 g·mol−1
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