PB 28 dihydrochloride | CAS 172906-90-0

Element: dihydrochloride

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C-S » Chemicals » dihydrochloride-PX81294

Identification

PB 28 dihydrochloride

CAS:

172906-90-0

EINECS:

Molecular Formula:

C₂₄H₃₈N₂O

MDL:

MFCD06798349

SMILES:

COC1=CC=CC2=C1CCCC2CCCN3CCN(CC3)C4CCCCC4.Cl.Cl

Synonym:

Description

PB 28 dihydrochloride is a high affinity selective σ2 receptor Activators (K_i values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. PB 28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum (EC₅₀ values are 2.62 and 3.96 μM respectively). PB 28 dihydrochloride also displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.