Methanesulfonamide,N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-,dihydrochloride (9CI) ; E 4031 ; Methanesulfonamide,N-[4-[[1-[2-(6-methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]-,hydrochloride (1:2)
Description
E-4031 dihydrochloride is a K+ channel blocker. Lead compound to investigate class III antiarrhythmic drugs. E-4031 dihydrochloride is a specific blocker of delayed rectifier current (I(kr)). Blocks the human ether-a-go-go-related gene (HERG) at all pulse frequencies (frequency-independent block) without significant recovery at rest.