HA-1077 dihydrochloride | CAS 103745-39-7

Element: dihydrochloride 1077

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C-S » Chemicals » dihydrochloride-PX70513

Identification

HA-1077 dihydrochloride

CAS:

103745-39-7

EINECS:

Molecular Formula:

C₁₄H₁₇N₃O₂S

MDL:

MFCD00153805

SMILES:

C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl.Cl

Synonym:

at 877 ; ha-1077 dihydrochloride salt >99% ; ha-1077-šeril ; hexahydro-1-(5-isoquinolinylsulfonyl)-1h-1,4-diazepine ; fasudil hydrochloride injection ; ha 1077 ; 1h-1,4-diazepine,hexahydro-1-(5-isoquinolinylsulfonyl)- (9ci) ; fasudilum [inn-latin] ; ha 1077, dihydrochloride, 99+% ; 1-(5-isoquinolinesulphonyl)homopiperazine ; 1-(5-isoquinoline-sulfonyl)-homopiperazine ; at877 ; fasudilum ; fasudil ; h-1077 dihydrochloride

Description

HA-1077 dihydrochloride has been shown to be a vasodilating agent as well as a potent inhibitor of Rock-2 (Rho-associated Kinase II), cGKI (cGMP-dependent protein kinase), PKA (cAMP-dependent protein kinase), MYLK, and CaMKII. Rho kinase signaling pathways are thought to cause invasion, migration, and proliferation of certain cells. Studies have shown this compound can also inhibit myosin light chain kinase in vitro and suppress cell rounding by myosin light chain phosphorylation. Mechanistic experiments report that HA-1077 inhibits vascular smooth muscle contraction by acting as a calcium channel protein inhibitor. HA-1077 dihydrochloride is an inhibitor of MSK1, PKC, PRK2 and Rsk-2.

Suppliers

Santa Cruz Biotechnology, Inc.

200583

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1H-1,4-diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-

Angene International Limited

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HA1077 (Fasudil, 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine•2HCl, 1-(5-Isoquinolinesulfonyl) homopiperazine•2HCl)

United States Biological

H1000

Prices & Availability

Data is processed

Properties for HA-1077 dihydrochloride

Molecular Weight:

291.37 g·mol−1

Density:

1.289 g/cm3

Melting point:

248-249° C

Boiling point:

506.2 °C at 760 mmHg

Flash point:

259.9 °C

Solubility:

H₂O: >200 mg/mL

Physical Description:

white crystalline solid

Safety & Transport Information

Storage temperature :

Store at RT

Alternative Distributors of [HA-1077 dihydrochloride]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Cfm Oskar Tropitzsch GmbH