10,11-Dihydro-10-hydroxy carbamazepine | CAS 29331-92-8

Element: carbamazepine dihydro hydroxy

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C-S » Chemicals » dihydro-hydroxy-carbamazepine-PX81188

Identification

10,11-Dihydro-10-hydroxy carbamazepine

CAS:

29331-92-8

EINECS:

Molecular Formula:

C₁₅H₁₄ N₂ O₂

MDL:

MFCD00871817

SMILES:

C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O

Synonym:

gp 47779 ; licarbazepine see 16178912 ; 10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide ; 10-hydroxy-10,11-dihydrocarbamazepine ; hydroxycarbamazepine ; 10-hydroxy-10,11-dihydrocarbamezepine ; gp 47779-d3 ; 10,11-dihydro-10-hydroxycarbazepine-d3 ; licarbazepine ; bia 2-005-d3 ; 10,11-dihydro-10-hydroxy ; bia 2-005 ; 10,11-dihydro-10-hydroxycarbamazepine

Description

10,11-Dihydro-10-hydroxy Carbamazepine is an oxcarbazepine metabolite which induces microsomal enzymes in hepatocytes via sodium channel protein inhibition. Identification techniques such as liquid chromatography-tandem mass spectrometry is used to quantify 10,11-Dihydro-10-hydroxy Carbamazepine in human plasma. In addition, 10,11-Dihydro-10-hydroxy Carbamazepine promotes the release of hippocampal monoamines and produces a dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs) of rat striatum. Furthermore, 10,11-Dihydro-10-hydroxy Carbamazepine reduces calcium ion concentration via a decrease in high-voltage-activated (HVA) Ca2+ currents evoked by membrane depolarization which is independent of dihydropyridine-sensitive channels.

Suppliers

Aozeal Certified Standards (AOCS), Inc.

O0006.02

Chemlyte Solutions

CS20526156

AK Scientific, Inc.

AS21666498

Santa Cruz Biotechnology, Inc.

206270

Dayang Chem (Hangzhou) Co.,Ltd.

DC353414136

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CAS equal suppliers

licarbazepine

Hangzhou MolCore BioPharmatech Co.,Ltd.

MC425457

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Leap Chem Co., Ltd

LC234702

Licarbazepine

Finipharma Ltd

F182364

Carbamazepine Impurity 1

Aozeal Certified Standards (AOCS), Inc.

C0001.08

10,11-Dihydro-10-hydroxycarbamazepine

Hangzhou Trylead Chemical Technology Co., Ltd.

HTCT340417020

10,11-Dihydro-10-hydroxycarbamazepine

CM Fine Chemicals

CFC12585032

10,11-Dihydro-10-hydroxycarbamazepine

Sigma-Aldrich International GmbH

SI23687104

10-Hydroxy-10,11-dihydro-5hdibenzo[b,f]azepine-5-carboxamide

BLD Pharmatech Ltd

BP756022680

10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide

Ambeed, Inc.

A334944

5H-dibenz[b,f]azepine-5-carboxamide, 10,11-dihydro-10-hydroxy-

Angene International Limited

AGN-PC-07A1XA

(±)-10-Hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide

Hangzhou Yuhao Chemical Technology Co., Ltd

LX2341

Prices & Availability

Data is processed

Properties for 10,11-Dihydro-10-hydroxy carbamazepine

Molecular Weight:

254.28 g·mol−1

Density:

1.336 g/cm3

Melting point:

186-189°C

Boiling point:

431.3°C at 760 mmHg

Flash point:

214.6°C

Solubility:

Soluble in Chloroform, Dimethyl Sulfoxide and Ethanol

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R36 - Irritating to eyes
R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment

Safety Codes:

S16 - Keep away from sources of ignition - No smoking
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S61 - Avoid release to the environment. Refer to special instructions/safety data sheet

Hazard Symbols:

N, Xn, F

Storage temperature :

Store at RT

Alternative Distributors of [10,11-Dihydro-10-hydroxy carbamazepine]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Synfine Research Inc. | Clearsynth Canada INC.