13,14-dihydro-16,16-difluoro Prostaglandin F2alpha

Prostaglandin F2α (PGF2α) causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity. 13,14-dihydro-16,16-difluoro PGF2α is an analog of PGF2α. While its biological activities have not been evaluated, it should be noted that the addition of two electron-withdrawing fluorine atoms has been used to stabilize prostanoids and significantly delay degradation in vivo. Importantly, 13,14-dihydro PGE1 has activity that is comparable to that of PGE1, suggesting that this analog of PGF2α could be biologically active.