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5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one[Intermediates of Pirenzepine]

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Formula: C14H10ClN3O2
CAS: 28797-48-0
search Element: benzodiazepine intermediates chloroacetyl pirenzepine dihydro pyrido
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Identification

Structural Formula
5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one[Intermediates of Pirenzepine]
CAS:
28797-48-0
EINECS:
249-227-9
Molecular Formula:
C14H10ClN3O2
MDL:
MFCD01948712
SMILES:
ClCC(=O)n1c2ncccc2[nH]c(=O)c2ccccc12
Synonym:
11-(2-chloroacetyl)-5h-pyrido[2,3-b][1,4]benzodiazepin-6-one ; 11-(chloroacetyl)-5,11-dihydro-6h-pyrido[3,2-c][2]benzazepin-6-one ; 11-(2-chloroacetyl)-5h-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11h)-one ; 5,11-dihydro-11-chloroacetyl-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one ; 1-(2-chloroacetyl)-5,11-dihydro-pyrido-[2,3-b][1,4]benzodiazepin-6-one ; 5,11-dihydro-11-chloroacetyl-6h-pyridop2,3-b][1,4]benzodiazepine-6-one ; 5,11-dihydro-11-chloroacetyl-6h-pyrido[2,3-b][1,4]benzodiazepine-6-one ; 11-(chloroacetyl)-5,11-dihydro-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one ; 11-(2-chloroacetyl)-5,11-dihydro-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one ; 5,11-dihydro-11-chloroacetyl-6h-pyrido[2,3-b][1,4]benzodiazepin-6-one(dcpbo)


Description

5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one is an intermediate of pirenzepine. Pirenzepine is a selective antagonist for the M1 muscarinic receptor (mAChR) and is reported to block presynaptic M1 receptors as well as some reported inverse agonist activity. A study investigating the pharmacological characterization of the muscarinic receptors associated with ACh-induced pulmonary vasodilation in a rabbit model of pulmonary hypertension determined the IC50 to be 2.51x10-7M. Additional research studies have investigated the role of pirenzepine in the pathophysiology of myopia. Other M1 receptor antagonists offered include telenzepine.


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5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one [Intermediates of Pirenzepine ]
Santa Cruz Biotechnology, Inc.
sc-336962

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Properties for 5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one[Intermediates of Pirenzepine]

Molecular Weight:
287.7 g·mol−1
Density:
1.415
Melting point:
215.47 °C (Predicted)
Boiling point:
~481.1 °C at 760 mmHg (Predicted)
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
    • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

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Alternative Distributors of [5,11-Dihydro-11-chloroacetyl-6H-pyrido[2,3-b][1,4]benzodiazepine-6-one[Intermediates of Pirenzepine]]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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