Diazoxide | CAS 364-98-7 | Chemical-Suppliers

Element: diazoxide

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C-S » Chemicals » diazoxide-PX66439

Identification

Diazoxide

CAS:

364-98-7

EINECS:

Molecular Formula:

C₈H₇ Cl N₂ O₂ S

MDL:

MFCD00078578

SMILES:

CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl

Synonym:

srg 95213 ; 2h-1,2,4-benzothiadiazine,7-chloro-3-methyl-, 1,1-dioxide ; mutabase ; diazossido ; nsc 76130 ; proglycem ; nsc64198 ; 3-methyl-7-chloro-1,2,4-benzothiadiazine1,1-dioxide ; eudemine ; sch-6783 ; hyperstat ; nsc-64198 ; srg95213 ; eudemine injection ; hypertonalum ; diazoxide ; 7-chloro-3-methyl-2h-1,2,4-benzothiadiazine 1,1-dioxide ; sch 6783 ; 4h-1,2,4-benzothiadiazine,7-chloro-3-methyl-, 1,1-dioxide (7ci) ; proglicem ; dizoxide

Description

Diazoxide is a benzothiadiazine derivative which functions as a selective KIR6 (ATP-dependent K⁺) channel activator and calcium channel blocker. As a result membrane permeability increases the flow of K⁺ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in smooth muscle. Studies suggest that Diazoxide acts as a peripheral vasodilator. In addition, Diazoxide is used in diabetic studies to increase glucose concentrations in plasma, inhibit the secretion of insulin by β cells of the pancreas, increase the release of catecholamines, and hepatic output of glucose in vitro.

Suppliers

Chemlyte Solutions

CS162486

Aozeal Certified Standards (AOCS), Inc.

D0210.00

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI6212484

Arcadia Biotechnology

AB189567

BoomKing Industrial Co.,Limited

BIC2791116

Sancai Industry Co.,Ltd.

SIC216864

CSNpharm, Inc.

CSN12647

Sigma-Aldrich International GmbH

SI288864

Finetech Industry Limited

FIL225900

Xingrui Industry Co., Limited

XIL2611044

BOC Sciences

BS108324

Leap Chem Co., Ltd

LC162486

Santa Cruz Biotechnology, Inc.

200980

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CAS equal suppliers

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

BLD Pharmatech Ltd

BP495014850

2H-1,2,4-benzothiadiazine, 7-chloro-3-methyl-, 1,1-dioxide

Angene International Limited

AGN-PC-0O9CRO

Prices & Availability

Data is processed

Properties for Diazoxide

Molecular Weight:

230.68 g·mol−1

Density:

1.61 g/cm3

Melting point:

>310 °C

Boiling point:

414.8°C at 760 mmHg

Flash point:

204.7°C

Solubility:

0.1 M NaOH: soluble

Safety & Transport Information

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of Cl−, SOx, and NOx.

Risk Codes:

R22 - Harmful if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S22 - Do not breathe dust
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing

Hazard Symbols:

Storage temperature :

Store at RT

Alternative Distributors of [Diazoxide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

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