Demethylasterriquinone B1 | CAS 78860-34-1

Element: demethylasterriquinone

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C-S » Chemicals » demethylasterriquinone-PX78309

Identification

Demethylasterriquinone B1

CAS:

78860-34-1

EINECS:

Molecular Formula:

C₃₂H₃₀N₂O₄

MDL:

MFCD06410990

SMILES:

CC(=CCC1=CC=CC2=C1NC=C2C3=C(C(=O)C(=C(C3=O)O)C4=C(NC5=CC=CC=C54)C(C)(C)C=C)O)C

Synonym:

dmaq-b1 ; daq b1 ; demethylasterriquinone b1 ; l-783,281 ; 2-[2-(1,1-dimethylallyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1h-indol-3-yl][1,4]benzoquinone ; 2-(2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl)-3,6-dihydroxy-5-(7-(3-methyl-2-butenyl)-1h-indol-3-yl)-2,5-cyclohexadiene- ; 2,5-dihydroxy-3-[7-(3-methyl-but-2-enyl)-1h-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1h-indol-3-yl]-[1,4]benzoquinone ; 2-[2-(1,1 dimethyl-2-propenyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1h-indol-3-yl]-2,5-cyclohexadien-1,4-dione ; 2-[2-(1,1-dimethyl-2-propenyl)-1h-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methyl-2-butenyl)-1h-indol-3-yl]-2,5-cyclohexadiene-1,4-dione

Description

Demethylasterriquinone B1 is a cell-permeable asymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC₅₀ ~ 6 μM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Demethylasterriquinone B1 also acts as an agonist for Trk A, Trk B and Trk C (the neurotrophin receptors TrkA, B, and C) in both cortical neurons and dorsal root ganglion neurons (~ 20 μM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway. Demethylasterriquinone B1 is an activator of insulin R.

Suppliers

Santa Cruz Biotechnology, Inc.

203025

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Properties for Demethylasterriquinone B1

Molecular Weight:

506.59 g·mol−1

Density:

1.34 g/cm³ (Predicted)

Boiling point:

780.16° C at 760 mmHg (Predicted)

Solubility:

Soluble in DMSO (100 mM).

Safety & Transport Information

Storage temperature :

Desiccate at -20°C

Alternative Distributors of [Demethylasterriquinone B1]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

BOC Sciences

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