Deguelin | CAS 522-17-8 | Chemical-Suppliers

Element: deguelin

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C-S » Chemicals » deguelin-PX78920

Identification

Deguelin

CAS:

522-17-8

EINECS:

Molecular Formula:

C₂₃H₂₂ O₆

MDL:

MFCD01740600

SMILES:

CC1(C=CC2=C(O1)C=CC3=C2O[C@@H]4COC5=CC(=C(C=C5[C@@H]4C3=O)OC)OC)C

Synonym:

3h-bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth ; ccris 8104 ; (7as-cis)-oxy- ; 3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-,(7as-cis)- ; 3,3-dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one ; 3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one,13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7as,13as)- (9ci) ; 3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one,13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl- (7ci,8ci) ; (-)-cis-deguelin ; 12a-deoxytephrosin ; (-)-deguelin ; 3h-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7ah)-one,13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7as,13as)- ; deguelin (6ci) ; (7as,13as)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one ; deguelin

Description

Deguelin is a natural product that displays profound antiproliferative activity. Deguelin induces apoptosis, mediated through AKT/PKB signaling pathways in malignant and premaligant human bronchial epithelia (HBE) cells, with only minimal effects on normal HBE cells. Deguelin inhibits AKT by both PI 3-kinase dependent and PI 3-kinase independent pathways. Deguelin has displayed anti-tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in tumor models. Deguelin has also been shown to inhibit Cox-2 expression.

Suppliers

Chengdu Pufeide Biotech. Co., Ltd

CPB2641056

CSNpharm, Inc.

CSN13985

Pharmacore Co., Limited

PL184552

Leap Chem Co., Ltd

LC144432

Santa Cruz Biotechnology, Inc.

200657

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Prices & Availability

Data is processed

Properties for Deguelin

Molecular Weight:

394.42 g·mol−1

Density:

1.255 g/cm3

Melting point:

85-87 °C(lit.)

Boiling point:

560.1°C at 760 mmHg

Flash point:

244.7°C

Solubility:

DMSO: >10 mg/mL

Safety & Transport Information

Safety Codes:

S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes

Storage temperature :

-20°C

Alternative Distributors of [Deguelin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

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MSDS:

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