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Debromohymenialdisine

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Formula: C11H11 N5 O2
CAS: 75593-17-8
search Element: debromohymenialdisine
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Identification

Structural Formula
Debromohymenialdisine
CAS:
75593-17-8
EINECS:
Molecular Formula:
C11H11 N5 O2
MDL:
MFCD04037016
SMILES:
C1CNC(=O)C2=C(/C1=C/3C(=O)N=C(N3)N)C=CN2
Synonym:
Pyrrolo[2,3-c]azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (Z)- ; (Z)-2-Debromohymenialdisine ; (Z)-Debromohymenialdisine ; Debromohymenialdesine ; Debromohymenialdisine ; SKF 108753 ; Pyrrolo[2,3-c]azepin-8(1H)-one,4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)-


Description

Debromohymenialdisine is an inhibitor of G2 DNA damage checkpoint (IC50 = 8 μM) and check point kinases 1 (Chk1) and 2 (Chk2) (IC50 = 3 μM and IC50 = 3.5 μM, respectively). Differing from many other checkpoint inhibitors, Debromohymenialdisine does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related protein. Debromohymenialdisine also inhibits MAP kinase kinase 1 (MEK-1) (IC50 = 881 nM) but is not as potent as 10Z-hymenialdisine (IC50 = 6 nM).


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Santa Cruz Biotechnology, Inc.
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CAS equal suppliers

(Z)-2-Debromohymenialdisine
Leap Chem Co., Ltd
LC14584374

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Properties for Debromohymenialdisine

Molecular Weight:
244.2294 g·mol−1
Density:
1.82 g/cm3 at 20° C
Melting point:
>250 °C (dec.)
Boiling point:
599.75° C (Predicted)
Solubility:
Soluble in DMSO, methanol, and 100% ethanol.
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Safety & Transport Information

Storage temperature :
-20 °C Freezer, Under Inert Atmosphere
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Alternative Distributors of [Debromohymenialdisine]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

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MSDS:
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