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Daphnetin

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Formula: C9H6O4
CAS: 486-35-1
search Element: daphnetin
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Identification

Structural Formula
Daphnetin
CAS:
486-35-1
EINECS:
207-632-8
Molecular Formula:
C9H6O4
MDL:
MFCD00016977
SMILES:
C1=CC(=C(C2=C1C=CC(=O)O2)O)O
Synonym:
daphnetol ; daphnetin ; daphnetin(p) ; daphenetin ; 7,8-dihydroxycoumarin ; daphetin ; 7,8-dihydroxy-coumari ; 7,8-dihydroxy-chromen-2-one ; akos 213-37 ; 7,8-diydroxycoumarin


Description

Daphnetin is a coumarin analog that acts as an inhibitor of several protein kinases. Inhibits EGFR kinase (IC50 = 7.67 μM), PKA (IC50 = 9.33 μM), and PKC (IC50 = 25 μM), in vitro. The inhibition of EGFR kinase by daphnetin was competitive to ATP and non-competitive to the peptide substrate. Also acts as a potent antioxidant and anti-malarial agent.


Suppliers

Ambeed, Inc.
A811058
+
Chengdu Pufeide Biotech. Co., Ltd
CPB2971188
+
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI6212484
+
CSNpharm, Inc.
CSN10745
Xiamen Hisunny Chemical Co., Ltd.
XHC2971188
+
Santa Cruz Biotechnology, Inc.
203022
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CAS equal suppliers

7,8-dihydroxycoumarin
Indofine Chemical Co, Inc.
D-109
7,8-Dihydroxycoumarin
Chemieliva Pharmaceutical Co., Ltd.
CP7352205
7,8-Dihydroxycoumarin
Evonik ( formerly Wilshire Technologies, Inc. )
E10084032
7,8-Dihydroxycoumarin
Leap Chem Co., Ltd
LC3781134
7,8-Dihydroxycoumarin
Hangzhou Lingrui Chemical Co., Ltd.
HLC7352940
7,8-Dihydroxycoumarin
Zehao Industry Co., Ltd.
ZI5041512
7,8-Dihydroxycoumarin (Daphnetin)
Molekula
73797541
2H-1-benzopyran-2-one, 7,8-dihydroxy-
Angene International Limited
AGN-PC-0LPKDH

Prices & Availability




Data is processed


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Properties for Daphnetin

Molecular Weight:
178.14 g·mol−1
Melting point:
265-268 °C (dec.)
Solubility:
DMSO or EtOH
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Hazard Statements

GHS06

GHS06
Toxic
  • Acute toxicity (oral, dermal, inhalation), categories 1, 2, 3

Safety & Transport Information

Risk Codes:
R25 - Toxic if swallowed
R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36 - Wear suitable protective clothing
Hazard Symbols:
Xi
Hazard symbol Xi
x

Alternative Distributors of [Daphnetin]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

3B Scientific Corporation | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | Carl Roth GmbH + Co KG | Chengdu Conut Intl. Co., Ltd. | Cfm Oskar Tropitzsch GmbH | BOC Sciences | Gihi Chemicals Co., Limited

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