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DAPH

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Formula: C20H15 N3 O2
CAS: 145915-58-8
search Element: daph
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Identification

Structural Formula
DAPH
CAS:
145915-58-8
EINECS:
Molecular Formula:
C20H15 N3 O2
MDL:
MFCD00236442
SMILES:
C1=CC=C(C=C1)NC2=C(C=C3C(=C2)C(=O)NC3=O)NC4=CC=CC=C4
Synonym:
4,5-dianilinophthalimide, 5,6-bis(phenylamino)-1h-isoindole-1,3(2h)-dione, cgp 52411 ; cgp 52411 ; 1h-isoindole-1,3(2h)-dione,5,6-bis(phenylamino)- ; daph/cgp 52411 ; 4,5-dianilinophthalimide


Description

DAPH is a tyrosine kinase inhibitor, which suppresses and reverses the formation of Aβ42 fibers in neurons. DAPH displays specificity towards the EGFR kinase3 receptor. Studies suggest that DAPH can attenuate phenylephrine-induced endothelium contraction in aortic rings. It is known that Aβ42 proteins are composed of β sheets that are arranged parallel to the fibril axis and are several micrometers in length. DAPH is a useful tool in inhibiting these proteins because it can disrupt fibril formation which is vital for β sheet formation.


Suppliers

Santa Cruz Biotechnology, Inc.
200698
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CAS equal suppliers

CGP 52411
Leap Chem Co., Ltd
LC162486

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Data is processed


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Properties for DAPH

Molecular Weight:
329.358 g·mol−1
Density:
1.374
Melting point:
199-202°C
Solubility:
DMSO: ~30 mg/mL
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Safety & Transport Information

Safety Codes:
S36/37 - Wear suitable protective clothing and gloves
Storage temperature :
2-8°C
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Alternative Distributors of [DAPH]

Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
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Downloads

Mol File:
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MSDS:
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