Dantrolene sodium salt | CAS 24868-20-0

Element: dantrolene sodium salt

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Identification

Dantrolene sodium salt

CAS:

24868-20-0

EINECS:

Molecular Formula:

C₁₄H₉N₄NaO₅.7/2H₂O

MDL:

MFCD07357270

SMILES:

C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-].[Na]

Synonym:

c14069 ; dantrium ; dantrolene na ; sodium dantrolene ; dantrolene sodium ; dantrolene sodium (100 mg) ; dantrolene sodium hemiheptahydrate ; dantrium,1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinedione ; sodium 1-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-4-oxo-5h-imidazol-2-olate ; 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolinedione sodium salt ; dantamacrin ; 2,4-imidazolidinedione, 1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-, sodium salt, hydrate (2:7) ; hydantoin, 1-((5-(p-nitrophenyl)furfurylidene)amino)-, sodium salt, hydrate (2:7)

Description

Dantrolene is a small molecule inhibitor of the Ryanodine receptor and a calcium channel protein inhibitor (see Ryanodine). Blockade of Ca²⁺ release from the sarcoendoplasmic reticulum, strongly related to excitation and contraction of muscles, generates a muscle relaxant effect correlated with Dantrolene. The neurotoxicity presented by pronounced glutamate activity is correlated to excessive rises in cytoplasmic Ca²⁺ levels, and Dantrolene is accordingly indicated as a neuroprotective agent against neurotrasmitter-induced excitotoxicity. Dantrolene, Sodium Salt is an inhibitor of RyR-1 and RyR-3.

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