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Cyclosporin A

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Formula: C62H111N11O12
CAS: 59865-13-3
search Element: cyclosporin

Identification

Structural Formula
Cyclosporin A
CAS:
59865-13-3
EINECS:
Molecular Formula:
C62H111N11O12
MDL:
MFCD00274558
SMILES:
CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)CC=CC)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Synonym:
ol27-400 ; cipol n ; neoral ; restasis ; optimmune ; sandimmun ; neoplanta ; s7481f1 ; atopica ; lo-27400


Description

Cyclosporin A is a metabolite of the fungi Trichoderma polysporum, Cyclosporin A (CsA) is a cyclic polypeptide consisting of 9 amino-acids to inhibit nitric oxide synthesis induced by interleukin 1alpha, lipopolysaccharides and TNFα. CsA is an immunosuppressant. Studies in animals indicate that cyclosporin inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous hypersensitivity, experimental allergic encephalomyelitis, Freund's adjuvant arthritis, graft-versus-host disease and also T-cell dependent antibody production. Also inhibits lymphokine production and release and appears to block resting lymphocytes in the G0 or G1 phase of the cell cycle. CsA binds to cyclophilin and inhibits the T-cell receptor signal transduction pathway via the formation of cyclpsporin A-cyclophilin complex. The CsA-cyclophilin complex inhibits PP2 (calcineurin, a type 2B phosphatase). Calcineurin inhibition interferes with other physiological processes as well. It inhibits mitochondrial permeability transition pore opening. However, pore inhibition becomes less efficient at increasing Ca2+ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells.


Suppliers

Chemlyte Solutions
CS4681404
Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)
CI17947176
Shandong Minglang Chemical Co., Ltd
SMC9103640
H&Z Industry Co.,Ltd
HIC5202080
XD BIOCHEMS Ltd
XB3901170
Shandong SanYoung Industry Co., Ltd
SSI9103640
Autech Industry Co.,Limited
AIC7022808
Nantong Xindao Biotech Ltd
NXB6762704
AbbVie Inc.
A286572
R.J. Chemicals, Inc.
RC5201560
Indofine Chemical Co, Inc.
06-461
ACIC Fine Chemicals Inc.
AFC6242496
Alpha Biopharmaceuticals Co., Ltd.
AB8842652
CellMark AB
CA286858
Kingreat Chemistry Company Limited
KCCL8844420
X´ian Taicheng Chem Co., Ltd
XTC7543016
Caesar & Loretz GmbH
CL5201560
Xiamen Equation Chemical Co.,Ltd
XECC8324160
Daming Changda Co., Ltd.
DC6241872
Aecochem Corp.
AC3641092
Hangzhou Keying Chem Co., Ltd.
HKC7803120
Hangzhou Lingrui Chemical Co., Ltd.
HLC9103640
scienTEST - bioKEMIX GmbH
S-B6502600
Finetech Industry Limited
FIL6502600
Carbone Scientific Co., Ltd.
CS7282184
Pharmacore Co., Limited
PL5981794
Iris Biotech GmbH
LS-1021
CM Fine Chemicals
CFC4421768
AK Scientific, Inc.
AS4941482
Xingrui Industry Co., Limited
XIL7543016
BOC Sciences
BS312936
Amadis Chemical Company Limited
ACCL8064030
Leap Chem Co., Ltd
LC4681404
Santa Cruz Biotechnology, Inc.
3503
Dayang Chem (Hangzhou) Co.,Ltd.
DC8063224
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Prices & Availability




Data is processed


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Properties for Cyclosporin A

Molecular Weight:
1202.61 g·mol−1
Density:
1.02 g/cm3
Melting point:
148-151 °C
Boiling point:
1293.78° C at 760 mmHg
Solubility:
ethanol: 30 mg/mL
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Hazard Statements

GHS07

GHS03
Harmful
  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    - Respiratory tract irritation
    - Narcotic effects
  • Not used
  • with the "skull and crossbones" pictogram
  • for skin or eye irritation if:
  • the "corrosion" pictogram also appears
  • the "health hazard" pictogram is used to indicate respiratory sensitization
GHS08

GHS08
Health hazard
  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Safety & Transport Information

Risk Codes:
R11 - Highly flammable
R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed
R22 - Harmful if swallowed
R36 - Irritating to eyes
R40 - Limited evidence of a carcinogenic effect
R45 - May cause cancer
R60 - May impair fertility
Safety Codes:
S16 - Keep away from sources of ignition - No smoking
S22 - Do not breathe dust
S24/25 - Avoid contact with skin and eyes
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37 - Wear suitable protective clothing and gloves
S45 - In case of accident or if you feel unwell seek medical advice immediately (show the label where possible)
S53 - Avoid exposure - obtain special instructions before use
Hazard Symbols:
T, Xn, F
Hazard symbol T Hazard symbol F Hazard symbol Xn
Storage temperature :
2-8°C
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Alternative Distributors of [Cyclosporin A]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Inter-Chemical Ltd. | World Biopharma Group Limited / World (Jiangsu) Industry Co.,Ltd | Santec Chemicals Corp. | Chemwerth Inc. | Hangzhou Onicon Chemical Co., Ltd. | Hallochem Pharma Co., Ltd. | Molekula GmbH | CCS. CHEM. Co., Ltd. | CNCCC Sichuan Co., Ltd. | Nantong Chem-Tech. (Group) Co., Ltd. | Chemexcel International Ltd. | Golden Harvest Fine Chemical Co., Ltd. | Changzhou An-Yuan Imp. & Exp. Corporation | Jinan Jinao Chemical Development Co., Ltd. | Kinfon Pharmaceutical and Chemical Service Co., Ltd. | Shanghai Boyle Chemical Co., Ltd. | Discovery Fine Chemicals Limited | Chengdu Qiaofeng Technological Development Co., Ltd. | Shanghai AOKChem Group Limited | Suzhou Rovathin Pharmatech Co., Ltd | Shanghai Richem International Co., Ltd. | Hangzhou Think Chemical Co., Ltd. | Lanospharma Laboratories Co., Ltd. | Shanghai Tauto Biotech Co., Ltd. | TCS INDUSTRY LTD. | Jinan Great Chemical Co., Ltd. | East Chemical Industry Co., Ltd. | Taizhou Creating Chemical Co., Ltd. | King Tang Chemical Group Industry Co., Ltd. | Watson International Ltd | Cfm Oskar Tropitzsch GmbH | Yongyi Chemicals Group Co., Ltd. | Shanghai Arbor Chemical Co., Ltd. | BOC Sciences | Jinan Haohua Industry Co., Ltd. | Xiamen Hisunny Chemical Co., Ltd. | Clearsynth Canada INC. | scienTEST | Haihang Industry Co., Ltd.

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