Z-Cyclopentyl-AP4

Z-Cyclopentyl-AP4 is a Group III mGluR agonist that displays higher potency at mGluR-4 than mGluR-8 (EC₅₀ values are 49 and 124 µM respectively) with no activity at mGluR-7. Z-Cyclopentyl-AP4 also selectively inhibits synaptic activity in the lateral perforant pathway (IC₅₀ values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Conformationally restrained analog of L-AP4.