CRAC Channel Inhibitor, BTP2 is a cell-permeable analog of 3,5-bis(trifluoromethyl)pyrazole (BTP) which specifically inhibits CRAC-mediated calcium influx in T-cells with an IC50 about 10 nM and displays ~31-fold greater selectivity over VOC. CRAC Channel Inhibitor, BTP2 blocks the calcium-induced activation and translocation of nuclear factor of activated T-cells (NFAT). It does not affect the activation of NF-κB and AP-1. It potently inhibits cytokine production (IC50 = 1.7 μM for IL-2) and PBMC proliferation (IC50=190 nM).
Soluble in DMSO (>10 mg/ml), ethanol (~10 mg/ml), and DMF (~30 mg/ml).
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Safety & Transport Information
Risk Codes:
R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin
Safety Codes:
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice S36/37 - Wear suitable protective clothing and gloves
Hazard Symbols:
Xn
Storage temperature :
2-8°C
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Alternative Distributors of [CRAC Channel Inhibitor, BTP2]
Producers or manufacturers change the product range from time to time. Currently there are no other manufacturers known.
Element: 
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