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(-)-Cotinine

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Formula: C10H12N2O
CAS: 486-56-6
search Element: cotinine

Identification

Structural Formula
(-)-Cotinine
CAS:
486-56-6
EINECS:
207-634-9
Molecular Formula:
C10H12N2O
MDL:
MFCD00077696
SMILES:
CN1[C@H](CCC1=O)C2=CN=CC=C2
Synonym:
(?)-cotinine solution ; nih 10498 ; cotinine(rg) ; s-(-)-cotinine ; (-)-cotinine,98% ; l-cotinine ; (-)cotinine methanol solution ; (-)-cotinine ; (s)-2-pyrrolidinon ; cotinine


Description

(-)-Cotinine is a major nicotine metabolite. (-)-Cotinine has been shown to activate a subpopulation of α3/ α6β2 nAChRs in monkey striatum. It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours). (-)-Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.


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Xingrui Industry Co., Limited
XIL6962784
Santa Cruz Biotechnology, Inc.
205267
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Properties for (-)-Cotinine

Molecular Weight:
176.22 g·mol−1
Melting point:
40-42 °C(lit.)
Boiling point:
250 °C150 mm Hg(lit.)
Flash point:
>230 ºF
Solubility:
Soluble in water (partly), DMSO (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol, and chloroform.