Costunolide | CAS 553-21-9 | Chemical-Suppliers

Element: costunolide

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C-S » Chemicals » costunolide-PX244466

Identification

Costunolide

CAS:

553-21-9

EINECS:

Molecular Formula:

C₁₅H₂₀O₂

MDL:

MFCD00210262

SMILES:

C/C/1=CCC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C

Synonym:

costunolide, >=98% ; costunlide ; nsc 106404 ; costundide ; costulide ; cyclodeca[b]furan-2(3h)-one,3a,4,5,8,9,11a- ; custunolide ; costunolide ; costunolid ; costunolide, from auckiandialappa decne.

Description

Costunolide is a sesquiterpene lactone isolated from Magnolia sieboldii. The compound is described to act as an antioxidant, anti-mycobacterial, anti-inflammatory, and anti-viral, with cytotoxic activity. Additionally, Costunolide is reported to inhibit the activity of TERT (telomerase). Studies indicate that Costunolide activates JNK downstream of ROS in leukemia cells, and upstream of Bcl-2. The compound has also been suggested to act as an inhibitor of NOS (nitric oxide synthase) and the VEGFR KDR/Flk-1 signaling pathway.

Suppliers

Chengdu Pufeide Biotech. Co., Ltd

CPB3631452

Conscientia Industrial Co., Ltd (Zhejiang Conscientia Pharmaceutical)

CI7593036

Chemlyte Solutions

CS198594

Autech Industry Co.,Limited

AIC2971188

Ambeed, Inc.

A496529

H&Z Industry Co.,Ltd

HIC220880

Indofine Chemical Co, Inc.

027502

Xiamen Equation Chemical Co.,Ltd

XECC3521760

CSNpharm, Inc.

CSN16398

Pharmacore Co., Limited

PL253759

Xingrui Industry Co., Limited

XIL3191276

Capot Chemical Co., Ltd.

6258

Zehao Industry Co., Ltd.

ZI264792

BOC Sciences

BS132396

Leap Chem Co., Ltd

LC198594

Santa Cruz Biotechnology, Inc.

203555

Dayang Chem (Hangzhou) Co.,Ltd.

DC3411364

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CAS equal suppliers

(3aS,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one

BLD Pharmatech Ltd

BP1742452272

Prices & Availability

Data is processed

Properties for Costunolide

Molecular Weight:

232.32 g·mol−1

Density:

1.04 g/cm³ (Predicted)

Melting point:

90.2° C (Predicted)

Boiling point:

385.45° C at 760 (Predicted)

Solubility:

Soluble in ethanol (50 mM), DMSO (47 mg/ml at 25° C), and water (<1 mg/ml at 25° C).

Hazard Statements

GHS03
Harmful

Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, categories 2, 3
Eye irritation, category 2A
Skin sensitization, category 1
Specific target organ toxicity following single exposure, category 3
- Respiratory tract irritation
- Narcotic effects

Not used

with the "skull and crossbones" pictogram
for skin or eye irritation if:
the "corrosion" pictogram also appears
the "health hazard" pictogram is used to indicate respiratory sensitization

Safety & Transport Information

Risk Codes:

R36/37/38 - Irritating to eyes, respiratory system and skin

Safety Codes:

S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice

Hazard Symbols:

Storage temperature :

Store at -20 °C

Alternative Distributors of [Costunolide]

Producers or manufacturers change the product range from time to time. The following companies
have appeared as suppliers in the past / currently not verified

Downloads

Mol File:

-/-

MSDS:

-/-

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